Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, China.
NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.
Clin Exp Optom. 2023 Nov;106(8):836-844. doi: 10.1080/08164622.2022.2116269. Epub 2022 Aug 31.
The measurement and simulation of corneal and lenticular curvature radii using a single swept-source biometry device enables a more thorough evaluation of the shape and refractive power of the cornea and lens during emmetropization or myopia progression in children.
This study aimed to evaluate the distribution characteristics of corneal and lenticular parameters in Chinese children with myopia and explored their association with other ocular components.
In this cross-sectional study, all ocular biometric parameters were measured using a Zeiss IOLMaster 700 Biometry. Simulations of the corneal and lenticular curvature radii were implemented using a customised MATLAB program based on cross-sectional swept-source optical coherence tomography images obtained from the same device. The associations of the calculated and simulated refractive powers of the cornea and lens with other ocular parameters were evaluated.
In total, 119 children with myopia were recruited. Boys had a deeper anterior chamber and longer axial length (AL) than girls, while girls had steeper anterior corneal and lenticular curvatures and greater corneal and lenticular power. Children aged 10 years and older showed a larger anterior lenticular radius of curvature (sR) and less lenticular power (P) than younger participants. There was a significant positive correlation between AL and the anterior corneal radius of curvature, regardless of sex or age. The sR exhibited a significant increasing trend, and P exhibited a declining trend with a longer AL only in children younger than 10 years.
AL is the most influential factor in the determination of spherical equivalent refractive error, while decreases in both corneal and crystalline lens power are significantly inversely correlated with axial elongation.
使用单一的扫频源生物测量仪测量和模拟角膜和晶状体曲率半径，能够更全面地评估儿童在正视化或近视进展过程中角膜和晶状体的形状和屈光力。
本研究旨在评估中国近视儿童的角膜和晶状体参数分布特征，并探讨其与其他眼部结构的关系。
在这项横断面研究中，使用蔡司 IOLMaster 700 生物测量仪测量所有眼部生物测量参数。使用基于同一设备获得的横断面扫频光学相干断层扫描图像的自定义 MATLAB 程序模拟角膜和晶状体曲率半径。评估计算和模拟的角膜和晶状体屈光力与其他眼部参数的相关性。
共纳入 119 名近视儿童。男孩的前房深度和眼轴（AL）比女孩深，而女孩的前角膜和晶状体曲率更陡，角膜和晶状体的屈光力更大。10 岁及以上的儿童的前晶状体曲率半径（sR）比年龄较小的儿童大，晶状体屈光力（P）较小。无论性别或年龄，AL 与角膜前曲率半径均呈显著正相关。sR 随 AL 延长而呈显著增加趋势，而 P 仅在年龄小于 10 岁的儿童中随 AL 延长而呈下降趋势。
AL 是决定等效球镜屈光度的最主要因素，而角膜和晶状体屈光力的下降与眼轴延长呈显著负相关。
