Henan University of Chinese Medicine, Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou 450046, China; Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou 450046, China.
Henan University of Chinese Medicine, Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou 450046, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Fitoterapia. 2024 Sep;177:106078. doi: 10.1016/j.fitote.2024.106078. Epub 2024 Jun 17.
A group of previously undescribed diarylheptanoids with mono/di-glucose substitution, diodiarylheptosides A-F (1-6), together with six known diarylheptanoids (7-12) were isolated from the rhizomes of Dioscorea nipponica. Their structures were established by comprehensive UV, IR, HR-ESI-MS and NMR analyses, and their absolute configurations were determined by a comparison of calculated and experimental ECD, some with optical rotations, after acid-hydrolysis. Moreover, bioassay results showed that compounds 3 and 11 exhibited stronger NO inhibitions on lipopolysaccharides-induced RAW 264.7 cells, with the IC values of 14.91 ± 0.62 and 12.78 ± 1.12 μM.
从穿龙薯蓣根茎中分离得到一组以前未描述的具有单/二葡萄糖取代的二芳基庚烷类化合物，即二碘二芳基庚糖苷 A-F（1-6），以及六个已知的二芳基庚烷类化合物（7-12）。通过综合 UV、IR、HR-ESI-MS 和 NMR 分析确定了它们的结构，并通过酸水解后的计算和实验 ECD 的比较，以及一些旋光度，确定了它们的绝对构型。此外，生物测定结果表明，化合物 3 和 11 对脂多糖诱导的 RAW 264.7 细胞的 NO 抑制作用更强，IC 值分别为 14.91 ± 0.62 和 12.78 ± 1.12 μM。
