RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
International Clinical Research Centre (ICRC), St Anne's University Hospital Brno (FNUSA), Brno, Czech Republic.
Sci Rep. 2024 Jun 19;14(1):14179. doi: 10.1038/s41598-024-64847-2.
Exposures to social and environmental stressors arise individual behavioural response and thus indirectly affect cardiometabolic health. The aim of this study was to investigate several social and environmental stressors and the paths of their influence on cardiometabolic health. The data of 2154 participants (aged 25-64 years) from the cross-sectional population-based study were analysed. The composite score of metabolic disorders (MS score) was calculated based on 5 biomarkers: waist circumference, blood pressure, fasting blood glucose, HDL-cholesterol, triglycerides. The effects of social stressors (education level, income), environmental stressors (NO, noise) and behavioural factors (unhealthy diet, smoking, alcohol consumption, sedentary behaviours) on MS score were assessed using a structural model. We observed a direct effect of education on MS score, as well as an indirect effect mediated via an unhealthy diet, smoking, and sedentary behaviours. We also observed a significant indirect effect of income via sedentary behaviours. The only environmental stressor predicting MS was noise, which also mediated the effect of education. In summary, the effect of social stressors on the development of cardiometabolic risk had a higher magnitude than the effect of the assessed environmental factors. Social stressors lead to an individual's unhealthy behaviour and might predispose individuals to higher levels of environmental stressors exposures.
暴露于社会和环境压力源会引发个体的行为反应，从而间接影响心血管代谢健康。本研究旨在探讨多种社会和环境压力源及其对心血管代谢健康影响的途径。本研究分析了来自横断面人群研究的 2154 名参与者（年龄 25-64 岁）的数据。根据 5 种生物标志物（腰围、血压、空腹血糖、HDL-胆固醇、甘油三酯）计算出代谢紊乱综合评分（MS 评分）。采用结构模型评估社会压力源（教育水平、收入）、环境压力源（NO、噪音）和行为因素（不健康饮食、吸烟、饮酒、久坐行为）对 MS 评分的影响。我们观察到教育对 MS 评分有直接影响，也观察到不健康饮食、吸烟和久坐行为的中介间接影响。我们还观察到收入通过久坐行为对 MS 评分有显著的间接影响。唯一能预测 MS 的环境压力源是噪音，它也介导了教育的作用。总之，社会压力源对心血管代谢风险发展的影响大于评估的环境因素的影响。社会压力源导致个体的不健康行为，可能使个体更容易暴露于更高水平的环境压力源。
