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慢性胃炎中的代谢动力学:根除幽门螺杆菌后尿液代谢谱分析

Metabolic dynamics in chronic gastritis: Examining urinary profiles post eradication.

作者信息

Musharaf Imshaal, Nashwan Abdulqadir J

机构信息

Department of Medicine, Jinnah Sindh Medical University, Karachi 0000, Pakistan.

Department of Nursing, Hamad Medical Corporation, Doha 3050, Qatar.

出版信息

World J Clin Cases. 2024 Jun 6;12(16):2698-2700. doi: 10.12998/wjcc.v12.i16.2698.

DOI:10.12998/wjcc.v12.i16.2698
PMID:38899295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11185323/
Abstract

Chronic gastritis is the persistent and insidious inflammation of the gastric lining. () has been identified as the most common cause of chronic gastritis and consequently elimination of can lead to its cure. This editorial explores the use of urinary metabolic profiles before and after eradication to identify biomarkers that can aid in prognosis and treatment. Despite providing promising insights, there are limitations such as a small sample size (17 patients), a narrow treatment period of 2 wk, and treatment heterogeneity, which raise concerns. Nevertheless, these findings have opened a gateway to enhancing the treatment and prognosis of chronic gastritis through urinary metabolomics.

摘要

慢性胃炎是胃黏膜的持续性隐匿性炎症。()已被确定为慢性胃炎最常见的病因,因此消除()可导致其治愈。本社论探讨根除前后尿代谢谱的应用,以识别有助于预后和治疗的生物标志物。尽管提供了有前景的见解,但存在样本量小(17例患者)、治疗期仅2周且治疗存在异质性等局限性,这引发了担忧。然而,这些发现为通过尿代谢组学改善慢性胃炎的治疗和预后打开了一扇门。

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本文引用的文献

1
Urinary metabolic profiles during eradication in chronic gastritis.慢性胃炎根除治疗期间的尿液代谢谱。
World J Clin Cases. 2024 Feb 16;12(5):951-965. doi: 10.12998/wjcc.v12.i5.951.
2
Metabolomics: an emerging but powerful tool for precision medicine.代谢组学:精准医学中一种新兴但强大的工具。
Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000588. doi: 10.1101/mcs.a000588.
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Chronic gastritis.慢性胃炎
Scand J Gastroenterol. 2015 Jun;50(6):657-67. doi: 10.3109/00365521.2015.1019918. Epub 2015 Apr 22.
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Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.幽门螺杆菌相关的慢性胃炎、临床综合征、癌前病变及胃癌发生的发病机制。
World J Gastroenterol. 2014 May 14;20(18):5461-73. doi: 10.3748/wjg.v20.i18.5461.
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