Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha 769008, India.
Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha 769008, India.
Drug Discov Today. 2024 Aug;29(8):104061. doi: 10.1016/j.drudis.2024.104061. Epub 2024 Jun 18.
Exosomes play a pivotal part in cancer progression and metastasis by transferring various biomolecules. Recent research highlights their involvement in tumor microenvironment remodeling, mediating metastasis, tumor heterogeneity and drug resistance. The unique cargo carried by exosomes garners the interest of researchers owing to its potential as a stage-specific biomarker for early cancer detection and its role in monitoring personalized treatment. However, unanswered questions hinder a comprehensive understanding of exosomes and their cargo in this context. This review discusses recent advancements and proposes novel ideas for exploring exosomes in cancer progression, aiming to deepen our understanding and improve treatment approaches.
外泌体通过传递各种生物分子在癌症进展和转移中起着关键作用。最近的研究强调了它们在肿瘤微环境重塑、介导转移、肿瘤异质性和耐药性中的作用。外泌体携带的独特货物引起了研究人员的兴趣，因为它有可能成为早期癌症检测的特定阶段生物标志物，并在监测个性化治疗中发挥作用。然而，一些悬而未决的问题阻碍了人们对这方面的外泌体及其货物的全面理解。本文讨论了最近的进展，并提出了探索癌症进展中外泌体的新想法，旨在加深我们的理解并改善治疗方法。
