Bodenheimer H C, Schaffner F
Am J Gastroenterol. 1979 Sep;72(3):285-96.
The immunologic features of diseases associated with primary biliary cirrhosis (PBC) such as Sjörgren's syndrome, scleroderma, rheumatoid arthritis and others are reviewed. Immunologic abnormalities involving both humoral and cell mediated immunity have been found in PBC. The morphologic and immunologic data have been used to propose a pathogenetic mechanism for PBC. Recent studies of penicillamine indicate that the drug may influence liver copper content and the deposition of immune complexes.
本文综述了与原发性胆汁性肝硬化（PBC）相关疾病的免疫学特征，如干燥综合征、硬皮病、类风湿关节炎等。在PBC中已发现涉及体液免疫和细胞介导免疫的免疫异常。形态学和免疫学数据已被用于提出PBC的发病机制。最近对青霉胺的研究表明，该药物可能影响肝脏铜含量和免疫复合物的沉积。
