乳铁蛋白及其衍生功能片段的协同作用作为一种有前途的抗毛霉病治疗药物。
Synergistic action of lactoferrin and its derived functional fragments as a promising therapeutic agent in combating mucormycosis.
机构信息
Department of Biophysics, All India Institute of Medical Sciences, New Delhi.
Department of Microbiology, All India Institute of Medical Sciences, New Delhi.
出版信息
Future Microbiol. 2024 Jul 2;19(10):857-866. doi: 10.1080/17460913.2024.2352263. Epub 2024 Jun 21.
Currently, we have limited armamentarium of antifungal agents against Mucorales. There is an urgent need to discover novel antifungal agents that are effective, safe and affordable. In this study, the anti-Mucorale action of native lactoferrin (LF) and its functional fragments CLF, RR6 and LFcin against three common Mucorale species are reported. The synergistic action of LF with antifungal agents like amphotericin B, isavuconazole and posaconazole was analyzed using checkerboard technique. All the three mucor species showed inhibition when treated with fragments. The checkerboard assay confirmed that native LF showed the best synergistic action against Mucorales in combination with Amphotericin B. These results highlight the potential therapeutic value of native LF against Mucorales.
目前，我们对抗真菌药物的选择有限，迫切需要发现有效、安全和负担得起的新型抗真菌药物。本研究报告了天然乳铁蛋白（LF）及其功能片段 CLF、RR6 和 LFcin 对三种常见毛霉科真菌的抗毛霉作用。使用棋盘技术分析了 LF 与两性霉素 B、伊曲康唑和泊沙康唑等抗真菌药物的协同作用。三种毛霉属真菌在片段处理下均显示出抑制作用。棋盘试验证实，天然 LF 与两性霉素 B 联合使用时对毛霉科显示出最佳的协同作用。这些结果突出了天然 LF 对抗毛霉科的潜在治疗价值。
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