Fernandes Kenya E, Carter Dee A
School of Life and Environmental Sciences, University of Sydney Sydney, NSW, Australia.
Front Microbiol. 2017 Jan 18;8:2. doi: 10.3389/fmicb.2017.00002. eCollection 2017.
Lactoferrin is a multifunctional iron-binding glycoprotein belonging to the transferrin family. It is found abundantly in milk and is present as a major protein in human exocrine secretions where it plays a role in the innate immune response. Various antifungal functions of lactoferrin have been reported including a wide spectrum of activity across yeasts and molds and synergy with other antifungal drugs in combination therapy, and various modes of action have been proposed. Bioactive peptides derived from lactoferrin can also exhibit strong antifungal activity, with some surpassing the potency of the whole protein. This paper reviews current knowledge of the spectrum of activity, proposed mechanisms of action, and capacity for synergy of lactoferrin and its peptides, including the three most studied derivatives: lactoferricin, lactoferrampin, and Lf(1-11), as well as some lactoferrin-derived variants and modified peptides.
乳铁蛋白是一种多功能的铁结合糖蛋白，属于转铁蛋白家族。它大量存在于牛奶中，并且是人类外分泌分泌物中的主要蛋白质，在先天免疫反应中发挥作用。乳铁蛋白的各种抗真菌功能已被报道，包括对酵母和霉菌的广泛活性以及在联合治疗中与其他抗真菌药物的协同作用，并且已经提出了各种作用模式。源自乳铁蛋白的生物活性肽也可以表现出强大的抗真菌活性，其中一些超过了完整蛋白质的效力。本文综述了乳铁蛋白及其肽的活性谱、作用机制和协同能力的现有知识，包括三种研究最多的衍生物：乳铁蛋白肽、乳铁防卫肽和Lf(1-11)，以及一些乳铁蛋白衍生的变体和修饰肽。
