Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, PR China.
Department of Neurology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, PR China.
Seizure. 2024 Aug;120:83-88. doi: 10.1016/j.seizure.2024.06.014. Epub 2024 Jun 19.
The analysis of long-term trends of mortality from epilepsy has not been conducted, which is crucial for estimating the future burden of epilepsy. We therefore aimed to investigate the long-term trends of mortality from epilepsy in the United States from 1979 to 2021.
The cause-of-death and demographic data were from the National Center for Health Statistics (1979-2021) and population estimates were from the US Census Bureau. We used the joinpoint regression model to analyze secular trends in the mortality of epilepsy spanning from 1979 to 2021. Age-adjusted mortality from epilepsy was assessed based on the year 2000 U.S. population data, stratified by age, sex, and race.
The age-adjusted mortality from epilepsy increased from 0.78 per 100,000 population in 1979 to 1.01 per 100,000 population in 2021, with an average annual percent change (AAPC) of 0.58% (95% confidence interval [CI]: 0.45% - 0.72%). The overall age-adjusted mortality of epilepsy had been on the rise between 2011 and 2021. The mortality rate generally increases with age. The mortality of epilepsy was higher in the Afro-American people and men. The mortality of epilepsy in both sexes declined first and then increased, with AAPC 1.02% (95% CI: 0.88%, 1.23%) in women and 0.10% (95% CI: -0.002%, 0.21%) in men. Mortality in all races including White, Afro-American people, and other races individuals fell first and then rose. The AAPC of mortality in White, other races, and Afro-American people were 0.89% (95% CI: 0.79%, 1.02%), -0.87% (95% CI: -1.84%, 0.88%), and -0.31% (95% CI: -0.48%, -0.13%), respectively.
Although the mortality rate from epilepsy has experienced a period of decline, it is worth noting that the last decade has seen a rapid increase. A comprehensive assessment of long-term trends in mortality from epilepsy holds significance for healthcare prioritization.
对癫痫死亡率的长期趋势进行分析尚未进行，这对于估计未来的癫痫负担至关重要。因此，我们旨在研究 1979 年至 2021 年美国癫痫死亡率的长期趋势。
死因和人口统计数据来自国家卫生统计中心（1979-2021 年），人口估计来自美国人口普查局。我们使用 joinpoint 回归模型分析了 1979 年至 2021 年癫痫死亡率的季节性趋势。根据 2000 年美国人口数据，按年龄、性别和种族对癫痫死亡率进行了年龄调整。
癫痫死亡率从 1979 年的 0.78/10 万上升至 2021 年的 1.01/10 万，年均变化百分比（AAPC）为 0.58%（95%可信区间：0.45%至 0.72%）。2011 年至 2021 年期间，癫痫的总体年龄调整死亡率一直在上升。死亡率随年龄增长而增加。非裔美国人和男性的癫痫死亡率更高。癫痫在两性中的死亡率先下降后上升，女性的 AAPC 为 1.02%（95%可信区间：0.88%至 1.23%），男性为 0.10%（95%可信区间：-0.002%至 0.21%）。包括白种人、非裔美国人和其他种族的所有人的死亡率先下降后上升。白种人、其他种族和非裔美国人的死亡率 AAPC 分别为 0.89%（95%可信区间：0.79%至 1.02%）、-0.87%（95%可信区间：-1.84%至 0.88%）和-0.31%（95%可信区间：-0.48%至-0.13%）。
尽管癫痫死亡率经历了一段时间的下降，但值得注意的是，过去十年呈快速上升趋势。对癫痫死亡率的长期趋势进行全面评估对于医疗保健的优先级排序具有重要意义。
