Brobakken Mathias Forsberg, Nygård Mona, Vedul-Kjelsås Einar, Harvey Philip D, Wang Eivind
Faculty of Health and Social Sciences, Molde University College, Molde, Norway; Department of Psychosis and Rehabilitation, Psychiatry Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Department of Psychosis and Rehabilitation, Psychiatry Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Schizophr Res. 2024 Aug;270:144-151. doi: 10.1016/j.schres.2024.06.027. Epub 2024 Jun 21.
Patients with schizophrenia suffer from physical health conditions, culminating in reduced physical functioning with enormous costs for patients and society. Although aerobic endurance and skeletal muscle strength, typically reduced in this population, relate to cognition and function, no study has explored their respective contributions to performance of functional skills and everyday tasks.
In a cross-sectional study, 48 outpatients (28/20 men/women; 35 ± 11(SD) years) with schizophrenia spectrum disorders (ICD-10; F20-25) were administered the UCSD Performance-based Skills Assessment-Brief (UPSA-B; functional skills), Specific Level of Functioning (SLOF; functional performance) and the Positive and Negative Syndrome (PANSS) scale. Peak oxygen uptake (V̇O) was assessed along with leg press maximal muscle strength (1RM) and mechanical power.
UPSA-B performance was associated with V̇O (r = 0.28,p < 0.05), accounting for 8 % (p < 0.05) of shared variance, but was unrelated to 1RM and mechanical power. The SLOF physical functioning domain was associated with V̇O (r = 0.30,p < 0.05) and 1RM (r = 0.24,p < 0.05), while SLOF personal care (r = 0.27,p < 0.05) and activities (r = 0.30,p < 0.05) were related only to V̇O. Hierarchical regression analyses revealed that while V̇O and age combined to account for 20 % (p < 0.05) of the variance in physical functioning, the contribution of 1RM was eliminated after adjusting for age. V̇O and negative symptoms combined predicted 24 % and 35 % of the variance in personal care and activities, respectively. UPSA-B scores did not add to the prediction of SLOF scores.
Although V̇O and 1RM both relate to functional outcomes, the combination of V̇O, age, and negative symptoms exert the greatest detrimental influence on functional performance beyond skills deficits.
精神分裂症患者存在身体健康问题，最终导致身体功能下降，给患者和社会带来巨大成本。尽管该人群的有氧耐力和骨骼肌力量通常会降低，且与认知和功能有关，但尚无研究探讨它们对功能技能表现和日常任务的各自贡献。
在一项横断面研究中，对48名患有精神分裂症谱系障碍（国际疾病分类第10版；F20 - 25）的门诊患者（28名男性/20名女性；35±11（标准差）岁）进行了加利福尼亚大学圣地亚哥分校基于表现的技能评估简表（UPSA - B；功能技能）、特定功能水平（SLOF；功能表现）以及阳性和阴性症状量表（PANSS）的评估。同时评估了峰值摄氧量（V̇O）以及腿举最大肌肉力量（1RM）和机械功率。
UPSA - B表现与V̇O相关（r = 0.28，p < 0.05），占共同方差的8%（p < 0.05），但与1RM和机械功率无关。SLOF身体功能领域与V̇O相关（r = 0.30，p < 0.05）和1RM相关（r = 0.24，p < 0.05），而SLOF个人护理（r = 0.27，p < 0.05）和活动（r = 0.30，p < 0.05）仅与V̇O相关。分层回归分析显示，虽然V̇O和年龄共同解释了身体功能方差的20%（p < 0.05），但在调整年龄后，1RM的贡献被消除。V̇O和阴性症状分别预测了个人护理和活动方差的24%和35%。UPSA - B分数并未增加对SLOF分数的预测。
尽管V̇O和1RM都与功能结果相关，但V̇O、年龄和阴性症状的组合对功能表现的不利影响最大，超出了技能缺陷的影响。
