Heggelund Jørn, Morken Gunnar, Helgerud Jan, Nilsberg Geir E, Hoff Jan
Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
BMC Res Notes. 2012 Jul 3;5:344. doi: 10.1186/1756-0500-5-344.
Patients with schizophrenia frequently have disabling gait deficits. The net mechanical efficiency of walking (ϵnet) is an accurate measure often used to evaluate walking performance. Patients with gait deficits have a reduced ϵnet with excessive energy expenditure during sub-maximal walking. Maximal strength training (MST) improves ϵnet in healthy individuals and is associated with reduced risk of mortality. The aim of this study was to investigate whether MST improves ϵnet in patients with schizophrenia.
Patients (ICD-10 schizophrenia, schizotypal or delusional disorders (F20-F29)) were included in a non-randomized trial. Patients were assigned to one of two groups: 1) MST consisting of 4x4 repetitions at 85-90% one repetition maximum (1RM) performed in a leg press apparatus or 2) playing computer games (CG). Both groups carried out their activity three days per week for eight weeks. 1RM, ϵnet at 60 watt walking, peak oxygen uptake (VO2peak), the Positive and Negative Syndrome Scale (PANSS) and the 36-items short form (SF-36) were measured pre and post intervention.
The baseline ϵnet was 17.3 ± 1.2% and 19.4 ± 3.0% in the MST (n = 6) and CG groups (n = 7), respectively, which is categorized as mechanical inefficiency. The MST group improved 1RM by 79 kg (p = 0.006) and ϵnet by 3.4% (p = 0.046) more than the CG group. The MST group improved 1RM and ϵnet, by a mean of 83 kg (p = 0.028) and 3.4% (p = 0.028), respectively. VO2peak at baseline was 34.2 ± 10.2 and 38.3 ± 9.8 ml·kg-1·min-1 in the MST and CG groups, respectively, and did not change (p > 0.05). No change was observed in PANSS or SF-36 (p > 0.05).
MST improves 1RM and ϵnet in patients with schizophrenia. MST could be used as a therapeutic intervention for patients with schizophrenia to normalize their reduced ϵnet.
精神分裂症患者常常存在致残性步态缺陷。步行的净机械效率（ϵnet）是一种常用于评估步行表现的精确指标。步态有缺陷的患者在次最大强度步行时，ϵnet降低且能量消耗过多。最大力量训练（MST）可提高健康个体的ϵnet，并与降低死亡风险相关。本研究的目的是调查MST是否能改善精神分裂症患者的ϵnet。
患者（国际疾病分类第10版精神分裂症、分裂型或妄想性障碍（F20 - F29））纳入一项非随机试验。患者被分为两组之一：1）在腿部推举器械上进行的MST，以85 - 90%的一次重复最大值（1RM）进行4组，每组4次重复；或2）玩电脑游戏（CG）。两组均每周进行3天活动，持续8周。在干预前后测量1RM、60瓦步行时的ϵnet、峰值摄氧量（VO2peak）、阳性和阴性症状量表（PANSS）以及36项简短形式健康调查（SF - 36）。
MST组（n = 6）和CG组（n = 7）的基线ϵnet分别为17.3±1.2%和19.4±3.0%，均属于机械效率低下。MST组的1RM比CG组提高了79 kg（p = 0.006），ϵnet比CG组提高了3.4%（p = 0.046）。MST组的1RM和ϵnet平均分别提高了83 kg（p = 0.028）和3.4%（p = 0.028）。MST组和CG组的基线VO2peak分别为34.2±10.2和38.3±9.8 ml·kg-1·min-1，且无变化（p>0.05）。PANSS或SF - 36未观察到变化（p>0.05）。
MST可改善精神分裂症患者的1RM和ϵnet。MST可作为精神分裂症患者的一种治疗干预措施，以使其降低的ϵnet恢复正常。
