Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Department of Østmarka, Division of Mental Health Care, St. Olavs University Hospital, Trondheim, Norway.
Scand J Med Sci Sports. 2019 Dec;29(12):1968-1979. doi: 10.1111/sms.13526. Epub 2019 Aug 18.
Patients with schizophrenia have impaired physical health. However, evidence of how skeletal muscle force-generating capacity (FGC), a key component of functional performance, may contribute to the impairment is scarce. Thus, the aim of this study was to investigate the patient groups' skeletal muscle FGC and its association with functional performance. Leg-press FGC was assessed along with a battery of functional performance tests in 48 outpatients (28 men, 34 ± 10 years; 20 women, 36 ± 12 years) with schizophrenia spectrum disorder (ICD-10, F20-29), and compared with 48 healthy age- and gender-matched references. Results revealed reduced one-repetition maximum (1RM) in men (-19%, P < .01) and a trend toward reduction in women (-13%, P = .067). The ability to develop force rapidly was also impaired (men: -30%; women: -25%, both P < .01). Patients scored worse than healthy references on all physical performance tests (stair climbing: -63%; 30-second sit-to-stand (30sSTS): -48%; six-minute walk test (6MWT): -22%; walking efficiency: -14%; and unipedal stance eyes open: -20% and closed: -73%, all P < .01). 1RM correlated with 6MWT (r = .45), stair climbing (r = -.44), 30sSTS (r = .43), walking efficiency (r = .26), and stance eyes open (r = .33) and closed (r = .45), all P < .01. Rapid force development correlated with 6MWT (r = .54), stair climbing (r = -.49), 30sSTS (r = .45), walking efficiency (r = .26), and stance eyes open (r = .44) and closed (r = .51), all P < .01. In conclusion, skeletal muscle FGC and functional performance are reduced in patients with schizophrenia and should be recognized as important aspects of the patient groups' impaired health. Resistance training aiming to improve these components should be considered an important part of clinical treatment.
精神分裂症患者的身体健康状况受损。然而，骨骼肌肉力量产生能力（FGC）作为功能表现的关键组成部分，可能会对这种损伤产生影响的证据却很少。因此，本研究旨在调查患者群体的骨骼肌 FGC 及其与功能表现的关系。在 48 名患有精神分裂症谱系障碍（ICD-10，F20-29）的门诊患者（28 名男性，34±10 岁；20 名女性，36±12 岁）中，评估了腿压 FGC 以及一系列功能表现测试，并与 48 名年龄和性别匹配的健康对照组进行了比较。结果显示，男性的 1 次重复最大力量（1RM）降低了（-19%，P<.01），女性则呈降低趋势（-13%，P=0.067）。快速产生力量的能力也受损（男性：-30%；女性：-25%，两者均 P<.01）。与健康对照组相比，患者在所有身体表现测试中得分都较差（爬楼梯：-63%；30 秒坐站（30sSTS）：-48%；6 分钟步行测试（6MWT）：-22%；行走效率：-14%；单足站立睁眼：-20%和闭眼：-73%，所有 P<.01）。1RM 与 6MWT（r=0.45）、爬楼梯（r=-0.44）、30sSTS（r=-0.43）、行走效率（r=-0.26）和站立睁眼（r=-0.33）和闭眼（r=-0.45）相关，所有 P<.01。快速力量发展与 6MWT（r=0.54）、爬楼梯（r=-0.49）、30sSTS（r=-0.45）、行走效率（r=-0.26）和站立睁眼（r=-0.44）和闭眼（r=-0.51）相关，所有 P<.01。总之，精神分裂症患者的骨骼肌 FGC 和功能表现均降低，应将其视为患者群体健康受损的重要方面。旨在改善这些方面的阻力训练应被视为临床治疗的重要组成部分。
