Department of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
Sci Rep. 2024 Jun 23;14(1):14424. doi: 10.1038/s41598-024-65107-z.
Metabolic syndrome (MetS) poses a significant public health challenge globally, including in Ethiopia, with risks for both mothers and children. Unfortunately, there is limited data on MetS in pregnant Ethiopian women. This study aims to evaluate the prevalence and factors associated with MetS in this population. A cross-sectional study was conducted using a systematic random sampling technique. Data were collected through face-to-face interviews using a structured questionnaire adapted from the World Health Organization Steps Survey Tool for Non-communicable Diseases. About five ml of fasting peripheral blood samples were collected from each participant. The Beckman Coulter DXC 700 AU clinical chemistry analyzer was employed for lipid profile and glucose analysis. Subsequently, data were inputted into Epi Data and later exported to SPSS Version 20 for further analysis. Bivariable and multivariable binary logistic regression analyses were carried out, with a predefined level of statistical significance at p < 0.05. A total of 318 pregnant women were included in this study. The prevalence of MetS was 13.2% (95% CI: 9.7, 17.0) based on the American Heart Association/National Heart Lung and Blood Institute definition. The most prevalent components of MetS were elevated triglyceride levels, reduced high-density lipoprotein levels, and elevated blood pressure. Unhealthy sleep duration (AOR = 5.6, 95% CI (2.4, 13.1), p < 0.001), high daily salt intake (AOR = 4.2, 95% CI (1.8, 9.5), p = 0.001), and alcohol consumption [AOR = 4.2, 95% CI (1.6, 10.9), p = 0.003] were significantly associated with MetS. The study reported a high prevalence of MetS in pregnant Ethiopian women. Factors including alcohol, high salt intake, and sleep disturbances were associated with MetS. Policymakers might utilize this data to create targeted interventions and public health policies for MetS among pregnant women, focusing on nutrition, sleep, and alcohol consumption during pregnancy to safeguard maternal and fetal health.
代谢综合征（MetS）在全球范围内构成了重大的公共卫生挑战，包括在埃塞俄比亚，这对母亲和儿童都存在风险。不幸的是，关于埃塞俄比亚孕妇代谢综合征的数据有限。本研究旨在评估该人群中代谢综合征的患病率和相关因素。采用系统随机抽样技术进行了横断面研究。通过面对面访谈，使用从世界卫生组织非传染性疾病步骤调查工具改编的结构化问卷收集数据。从每位参与者采集约 5 毫升空腹外周血样本。采用贝克曼库尔特 DXC 700 AU 临床化学分析仪进行血脂谱和血糖分析。随后，将数据输入 EpiData，然后导出到 SPSS 版本 20 进行进一步分析。进行了单变量和多变量二元逻辑回归分析，以 p < 0.05 为预设的统计学显著性水平。本研究共纳入 318 名孕妇。根据美国心脏协会/国家心肺血液研究所的定义，代谢综合征的患病率为 13.2%（95%CI：9.7,17.0）。代谢综合征最常见的成分是甘油三酯水平升高、高密度脂蛋白水平降低和血压升高。不健康的睡眠时长（AOR=5.6，95%CI（2.4,13.1），p<0.001）、高日常盐摄入量（AOR=4.2，95%CI（1.8,9.5），p=0.001）和饮酒（AOR=4.2，95%CI（1.6,10.9），p=0.003）与代谢综合征显著相关。本研究报告了埃塞俄比亚孕妇代谢综合征的高患病率。包括饮酒、高盐摄入量和睡眠障碍在内的因素与代谢综合征相关。决策者可以利用这些数据制定针对孕妇代谢综合征的干预措施和公共卫生政策，重点关注怀孕期间的营养、睡眠和饮酒，以保障母婴健康。
