Jia Xueqian, Zhu Lifu, Zhu Qixing, Zhang Jiaxiang
Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, PR China.
Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, PR China; Key Laboratory of Dermatology, Ministry of Education, The First Affiliated Hospital of Anhui Medical University, Hefei, PR China.
Autoimmun Rev. 2024 Jun;23(6):103576. doi: 10.1016/j.autrev.2024.103576. Epub 2024 Jun 21.
Mitochondria are the main sites of aerobic respiration in the cell and mainly provide energy for the organism, and play key roles in adenosine triphosphate (ATP) synthesis, metabolic regulation, and cell differentiation and death. Mitochondrial dysfunction has been identified as a contributing factor to a variety of diseases. The kidney is rich in mitochondria to meet energy needs, and stable mitochondrial structure and function are essential for normal kidney function. Recently, many studies have shown a link between mitochondrial dysfunction and kidney disease, maintaining mitochondrial homeostasis has become an important target for kidney therapy. In this review, we integrate the role of mitochondrial dysfunction in different kidney diseases, and specifically elaborate the mechanism of mitochondrial reactive oxygen species (mtROS), autophagy and ferroptosis involved in the occurrence and development of kidney diseases, providing insights for improved treatment of kidney diseases.
线粒体是细胞有氧呼吸的主要场所，主要为机体提供能量，在三磷酸腺苷（ATP）合成、代谢调节以及细胞分化和死亡中发挥关键作用。线粒体功能障碍已被确定为多种疾病的一个促成因素。肾脏富含线粒体以满足能量需求，稳定的线粒体结构和功能对于正常肾功能至关重要。最近，许多研究表明线粒体功能障碍与肾脏疾病之间存在联系，维持线粒体稳态已成为肾脏治疗的重要靶点。在这篇综述中，我们整合了线粒体功能障碍在不同肾脏疾病中的作用，并具体阐述了线粒体活性氧（mtROS）、自噬和铁死亡参与肾脏疾病发生发展的机制，为改善肾脏疾病的治疗提供见解。
