Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, 215123, China; Monash Suzhou Research Institute, Monash University, Suzhou, 215000, China; Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Monash Suzhou Research Institute, Monash University, Suzhou, 215000, China; Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Trends Immunol. 2024 Jul;45(7):549-563. doi: 10.1016/j.it.2024.06.001. Epub 2024 Jun 23.
Owing to its remarkable ease of use, ultrasound has recently been explored for stimulating or amplifying immune responses during cancer therapy, termed 'sono-immunotherapy'. Ultrasound can cause immunogenic cell death in cancer cells via thermal and nonthermal effects to regulate the tumor microenvironment, thereby priming anticancer immunity; by integrating well-designed biomaterials, novel sono-immunotherapy approaches with augmented efficacy can also be developed. Here, we review the advances in sono-immunotherapy for cancer treatment and summarize existing limitations along with potential trends. We offer emerging insights into this realm, which might prompt breakthroughs and expand its potential applications to other diseases.
由于其使用非常简便，超声最近被探索用于在癌症治疗期间刺激或增强免疫反应，称为“声免疫治疗”。超声可以通过热效应和非热效应引起癌细胞的免疫原性细胞死亡，从而调节肿瘤微环境，从而引发抗癌免疫；通过整合精心设计的生物材料，还可以开发出具有增强疗效的新型声免疫治疗方法。在这里，我们综述了癌症治疗中的声免疫治疗进展，并总结了现有局限性以及潜在趋势。我们为这一领域提供了新的见解，这可能会促使该领域取得突破，并将其应用扩展到其他疾病。
