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党参口服液物质基础及免疫增强活性研究

Study on the material basis and immunological enhancement activity of dangdi oral liquid.

作者信息

Zhou Zhihong, Liu Minzhuo, Zhao Xin, Li Haixia, Hu Qin, Jiang Zhiping

机构信息

Department of Pharmacy, Hunan Children's Hospital, Changsha, 410007, China.

College of Biological and Chemical Engineering, Changsha University, Changsha, 410022, China.

出版信息

Heliyon. 2024 May 29;10(11):e32160. doi: 10.1016/j.heliyon.2024.e32160. eCollection 2024 Jun 15.

DOI:10.1016/j.heliyon.2024.e32160
PMID:38912465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11190602/
Abstract

Studies have shown that a lot of traditional Chinese medicines could improve the immunity of the body. Dangdi oral liquid (DDO) was mainly composed of (Oliv.) Diels (Danggui), Libosch. (Dihuang), Bl. (Niuxi), Fisch. (Gancao). In this study, the rapid ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) method was used to identify the potentially effective compounds of DDO. Then the immune activity of DDO was measured by lymphocyte proliferation, macrophage phagocytic function, NK cell activity, delayed type hypersensitivity reaction, hemolytic plaque number, sIgA content and immune organ index. The results showed that a total of 51 compounds were identified. In addition, DDO could significantly promote the lymphocyte proliferation, improve macrophage phagocytic ability, NK cell activity, hemolytic plaque number, sIgA content and immune organ index compared with control group, and the medium dose possessed the best efficacy (P＜0.05). These results indicated that DDO could enhance the immunity of mice.

摘要

研究表明，许多中药可以提高机体免疫力。当归口服液（DDO）主要由当归（Oliv.）Diels、地黄Libosch.、牛膝Bl.、甘草Fisch.组成。本研究采用快速超高效液相色谱-四极杆飞行时间质谱联用（UPLC-Q-TOF/MS）方法鉴定DDO的潜在有效成分。然后通过淋巴细胞增殖、巨噬细胞吞噬功能、NK细胞活性、迟发型超敏反应、溶血空斑数、sIgA含量和免疫器官指数来测定DDO的免疫活性。结果表明，共鉴定出51种化合物。此外，与对照组相比，DDO能显著促进淋巴细胞增殖，提高巨噬细胞吞噬能力、NK细胞活性、溶血空斑数、sIgA含量和免疫器官指数，且中剂量组疗效最佳（P＜0.05）。这些结果表明，DDO可增强小鼠免疫力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/9c194619f0ed/gr10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/9c194619f0ed/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/019bac1a4951/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/c9c5f100b1e3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/d1e6dc075792/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/90541fe55bfc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/a77db75080fd/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/e7656a48071d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/9b433467cf5a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/9f1baf5d1815/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/01e0b8362dcf/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c07/11190602/9c194619f0ed/gr10.jpg

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