He Keting, Zhou Diwenxin, Pu Zhangya, Chen Shangci, Shen Yangfan, Zhao Shuai, Qian Xiaohan, Hu Qingqing, Wu Xiaoxin, Xie Zhongyang, Xu Xiaowei
Aging Dis. 2024 Jun 10;16(3):1347-1362. doi: 10.14336/AD.2024.0586.
Cellular senescence, characterized by irreversible cell cycle arrest, not only exists in age-related physiological states, but has been found to exist in various diseases. It plays a crucial role in both physiological and pathological processes and has become a trending topic in global research in recent years. Acute liver injury (ALI) has a high incidence worldwide, and recent studies have shown that hepatic senescence can be induced following ALI. Therefore, we reviewed the significance of cellular senescence in ALI. To minimize the potential confounding effects of aging on cellular senescence and ALI outcomes, we selected studies involving young individuals to identify the characteristics of senescent cells, the value of cellular senescence in liver repair, its regulation mechanisms in ALI, its potential as a biomarker for ALI, the prospect of treatment, and future research directions.
细胞衰老以不可逆的细胞周期停滞为特征，不仅存在于与年龄相关的生理状态中，还被发现在各种疾病中存在。它在生理和病理过程中都起着关键作用，并且近年来已成为全球研究的热门话题。急性肝损伤（ALI）在全球范围内发病率很高，最近的研究表明，ALI后可诱导肝脏衰老。因此，我们综述了细胞衰老在ALI中的意义。为了尽量减少衰老对细胞衰老和ALI结果的潜在混杂影响，我们选择了涉及年轻人的研究，以确定衰老细胞的特征、细胞衰老在肝脏修复中的价值、其在ALI中的调节机制、其作为ALI生物标志物的潜力、治疗前景以及未来的研究方向。
