Nelson Nicholas, Diaz Alejandro, Bouzarif Ghita, Chen Jenna, Doshi Nirmita, Mortimer Adam, Subramanian Indhu
Department of Medicine, Alameda Health System, Highland Hospital, Oakland, CA, USA.
J Addict Dis. 2025 Jul-Sep;43(3):288-293. doi: 10.1080/10550887.2024.2369744. Epub 2024 Jun 24.
Nitrous oxide is used medically as an anesthetic agent; in the food industry as a propellant for condiments; and recreationally for its euphoric and dissociative effects. We report three cases of nitrous oxide misuse causing severe, symptomatic cobalamin (vitamin B12) deficiency in which signs of nitrous oxide use per se, as well as signs of toxicity, were observed, including characteristic palmar calluses over the metacarpal heads, and frostbite. These signs may assist clinicians in the recognition of nitrous oxide use and the timely diagnosis of nitrous oxide toxicity.
一氧化二氮在医学上用作麻醉剂；在食品工业中用作调味品的推进剂；在娱乐方面因其欣快和解离作用而被使用。我们报告了3例一氧化二氮滥用导致严重的、有症状的钴胺素（维生素B12）缺乏的病例，其中观察到了一氧化二氮使用本身的迹象以及毒性迹象，包括掌骨头处典型的掌部老茧和冻伤。这些迹象可能有助于临床医生识别一氧化二氮的使用情况并及时诊断一氧化二氮毒性。
