Finch Amara, Joss-Moore Lisa, Allshouse Amanda A, Blue Nathan, Haas David M, Grobman William, Parry Samuel, Saade George, Silver Robert M
Department of Pediatrics, University of Utah, Salt Lake City, Utah.
Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah.
Am J Perinatol. 2025 Feb;42(3):310-319. doi: 10.1055/a-2351-9810. Epub 2024 Jun 25.
Maternal preconception diet influences pregnancy health and fetal outcomes. We examined the relationship between preconception fatty acid (FA) intake and uterine artery indices in mid-gestation in a large, heterogeneous cohort of nulliparous individuals.
This is a secondary analysis of the nuMom2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be) study. Dietary ω-6 and ω-3 FA intake was assessed with food frequency questionnaires and uterine artery indices were obtained via Doppler studies in the second trimester. For our primary outcome of pulsatility index (PI) > 1.6, we compared proportions by each dichotomous FA exposure and tested differences with chi-square test.
For PI > 1.6, odds ratio for the unfavorable FA quartile compared with remaining quartiles for the exposures were 0.96 to 1.25, = 0.157 (ω-6 FA); 0.97 to 1.26, = 0.124 (ω-3 FA); 0.87 to 1.14, = 1.00 (ω-6:ω-3 FA ratio).
No significant associations between self-reported maternal preconception ω-6 and ω-3 FA intake and uterine artery Doppler indices measured during the second trimester were observed.
· Maternal diet impacts pregnancy health/fetal outcomes.. · ω-3 and ω-6 FA intake influences cardiovascular health.. · FA intake may affect blood flow to fetoplacental unit.. · Results are limited by inadequate adherence to dietary recommendations..
孕前母亲饮食会影响孕期健康和胎儿结局。我们在一个大型、异质性的未生育个体队列中，研究了孕前脂肪酸（FA）摄入量与孕中期子宫动脉指数之间的关系。
这是对nuMom2b（未生育妊娠结局研究：监测准妈妈）研究的二次分析。通过食物频率问卷评估膳食ω-6和ω-3 FA摄入量，并在孕中期通过多普勒研究获得子宫动脉指数。对于我们的主要结局——搏动指数（PI）>1.6，我们比较了每种二分法FA暴露的比例，并通过卡方检验检测差异。
对于PI>1.6，与其余四分位数相比，不利FA四分位数的暴露比值比为0.96至1.25，P = 0.157（ω-6 FA）；0.97至1.26，P = 0.124（ω-3 FA）；0.87至l.14，P = 1.00（ω-6:ω-3 FA比值）。
未观察到自我报告的孕前母亲ω-6和ω-3 FA摄入量与孕中期测量的子宫动脉多普勒指数之间存在显著关联。
· 母亲饮食会影响孕期健康/胎儿结局。· ω-3和ω-6 FA摄入量会影响心血管健康。· FA摄入量可能会影响胎儿-胎盘单位的血流。· 结果受饮食建议依从性不足的限制。
