Martinović Anastasija, Axon David R
College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Diseases. 2024 Jun 4;12(6):120. doi: 10.3390/diseases12060120.
The purpose of this cross-sectional study was to investigate the relationship between Body Mass Index (BMI), cholesterol, and cancer in United States (US) adults. Data were collected from the 2020 Medical Expenditure Panel Survey (MEPS). Eligible participants were US adults (≥18 years) with data on BMI, cholesterol, and cancer status, who were alive at the end of the data collection period. An adjusted logistic regression model assessed associations between eight possible combinations of BMI and cholesterol status (independent variable) with cancer diagnosis (dependent variable). Among 27,805 individuals in the 2020 MEPS data, 20,818 met the eligibility criteria (weighted N = 252,340,615). Of these 2668 (weighted N = 29,770,359) had cancer and 18,150 (weighted N = 222,570,256) did not have cancer. In the adjusted logistic regression model, underweight and normal weight individuals with high cholesterol were associated with higher odds of cancer (odds ratio, OR = 2.002, and 95% confidence interval, CI = 1.032-3.885, and OR = 1.326 and 95% CI = 1.047-1.681, respectively), while obese individuals with normal cholesterol were associated with lower odds of cancer (OR = 0.681; 95% CI = 0.543-0.853) compared to normal weight individuals with normal cholesterol. This study offers insights into specific groups of individuals who may be prioritized for cancer prevention. Further research is required to investigate these findings in additional subpopulations.
这项横断面研究的目的是调查美国成年人的体重指数（BMI）、胆固醇与癌症之间的关系。数据来自2020年医疗支出面板调查（MEPS）。符合条件的参与者为有BMI、胆固醇和癌症状况数据的美国成年人（≥18岁），且在数据收集期结束时仍存活。一个校正后的逻辑回归模型评估了BMI和胆固醇状况的八种可能组合（自变量）与癌症诊断（因变量）之间的关联。在2020年MEPS数据中的27805名个体中，20818名符合资格标准（加权N = 252340615）。其中，2668名（加权N = 29770359）患有癌症，18150名（加权N = 222570256）未患癌症。在校正后的逻辑回归模型中，胆固醇高的体重过轻和正常体重个体患癌症的几率较高（优势比，OR = 2.002，95%置信区间，CI = 1.032 - 3.885；以及OR = 1.326，95% CI = 1.047 - 1.681），而胆固醇正常的肥胖个体与胆固醇正常的正常体重个体相比，患癌症的几率较低（OR = 0.681；95% CI = 0.543 - 0.853）。这项研究为可能被优先考虑进行癌症预防的特定个体群体提供了见解。需要进一步研究以在其他亚人群中调查这些发现。
