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通过气相色谱/质谱联用技术检测尿液样本中的O6-单乙酰吗啡以作为使用海洛因的证据。

Detection of O6-monoacetylmorphine in urine samples by GC/MS as evidence for heroin use.

作者信息

Fehn J, Megges G

出版信息

J Anal Toxicol. 1985 May-Jun;9(3):134-8. doi: 10.1093/jat/9.3.134.

DOI:10.1093/jat/9.3.134
PMID:3892162
Abstract

A method for qualitative and quantitative detection of nanogram amounts of O6-monoacetylmorphine (MAM) in urine samples of heroin abusers is presented. The detection of MAM is based on the alkaline solid phase extraction of the urine samples using an octadecyl column and transformation into the pentafluoropropionyl (PFP) derivatives. PFP-MAM is separated by capillary GC and identified mass spectrometrically by selected ion monitoring (SIM). The determination of the MAM levels was carried out by quantitative GC/SIM using nalorphine as the internal standard. A positive identification of MAM allows one to distinguish between a previous intake of heroin (or theoretically MAM) on the one hand, and an ingestion of morphine, codeine, opium, or poppy seed on the other.

摘要

本文介绍了一种定性和定量检测海洛因滥用者尿液样本中纳克量O6-单乙酰吗啡（MAM）的方法。MAM的检测基于使用十八烷基柱对尿液样本进行碱性固相萃取，并转化为五氟丙酰（PFP）衍生物。PFP-MAM通过毛细管气相色谱分离，并通过选择离子监测（SIM）进行质谱鉴定。MAM水平的测定通过使用烯丙吗啡作为内标物的定量气相色谱/选择离子监测（GC/SIM）来进行。MAM的阳性鉴定能够使人区分一方面是先前摄入过海洛因（或理论上的MAM），另一方面是摄入过吗啡、可待因、鸦片或罂粟籽。

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[Methodology and interpretation of morphiate detection in urine samples].
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