Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Research Center, Maruzen Pharmaceuticals Co., Ltd., Fukuyama, Hiroshima 729-3102, Japan.
Int J Mol Sci. 2024 Jun 16;25(12):6627. doi: 10.3390/ijms25126627.
3-(4-Hydroxy-3-methoxyphenyl)propionic acid (HMPA), also known as dihydroferulic acid, is a hydroxycinnamic acid derivative that can be derived from the microbial transformation of dietary polyphenols or naturally obtained from fermented foods. Although numerous studies have documented its antioxidant and anti-obesity effects, the effect of HMPA on muscle function remains unknown. This study investigated the effects of HMPA on muscle strength and exercise endurance capacity. Mice were orally administered low and high doses of HMPA for 14 days and subjected to grip force and treadmill exhaustion tests to evaluate muscle function. Our results showed that HMPA-administered groups significantly enhanced absolute grip strength ( = 0.0256) and relative grip strength ( = 0.0209), and low-dose HMPA decreased the plasma level of blood urea nitrogen after exercise ( = 0.0183), but HMPA did not affect endurance performance. Low-dose HMPA administration increased expression in sedentary mice ( = 0.0106), suggesting that low-dose HMPA may promote muscle development. Additionally, HMPA improved hepatic glucose and lipid metabolism, and inhibited muscular lipid metabolism and protein catabolism, as indicated by changes in mRNA expression levels of related genes. These findings suggest that HMPA may be a promising dietary supplement for muscle health and performance.
3-(4-羟基-3-甲氧基苯基)丙酸（HMPA），也称为二氢阿魏酸，是一种羟基肉桂酸衍生物，可来源于饮食多酚的微生物转化，或从发酵食品中天然获得。虽然许多研究已经记录了其抗氧化和抗肥胖作用，但 HMPA 对肌肉功能的影响仍不清楚。本研究探讨了 HMPA 对肌肉力量和运动耐力的影响。小鼠连续 14 天口服低剂量和高剂量 HMPA，并进行握力和跑步机衰竭试验以评估肌肉功能。我们的结果表明，HMPA 给药组可显著增强绝对握力（=0.0256）和相对握力（=0.0209），且低剂量 HMPA 可降低运动后血尿素氮的血浆水平（=0.0183），但 HMPA 对耐力性能没有影响。低剂量 HMPA 给药可增加安静小鼠的 表达（=0.0106），表明低剂量 HMPA 可能促进肌肉发育。此外，HMPA 改善了肝葡萄糖和脂质代谢，并抑制了肌肉脂质代谢和蛋白质分解代谢，这反映在相关基因的 mRNA 表达水平的变化上。这些发现表明，HMPA 可能是一种有前途的肌肉健康和性能的膳食补充剂。
