Chen Ling, Wu Le-Le, Yu Chang-Yin, Xu Zu-Cai, Huang Hao
Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Neurology, Xinqiao Hospital and the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Neurosci. 2025 Mar 5;19:1506566. doi: 10.3389/fnins.2025.1506566. eCollection 2025.
The gut-brain axis (GBA) represents a complex, bidirectional communication network that connects the central nervous system (CNS) and the gastrointestinal system. Our study aimed to explore the correlation between the intestinal microbiota and demyelinating diseases from a bibliometric perspective, focusing on research since 2014.
A comprehensive search was carried out on the Web of Science Core Collection (WoSCC) to locate studies on the intestinal microbiota and demyelinating diseases, with a focus on publications from 1 January 2014 to 29 March 2024. We visualized and analyzed the data using VOSviewer, CiteSpace, and Charticulator.
We gathered 429 scholarly articles on the intestinal microbiota and demyelinating disorders published in the past 10 years. Research concerning the intestinal microbiota and demyelinating diseases has demonstrated a consistent increase in frequency over time. The USA has the highest number of publications, while Canada has the highest average number of citations, reaching as high as 3,429, which is greater than that of the USA. Moreover, the journal with the highest number of publications was Frontiers in Immunology, with 33 publications and 1,494 citations. The majority of the scholars focused on "multiple sclerosis" and "gut microbiota," which are the primary keywords in the field of the intestinal microbiota and demyelinating diseases.
This study conducted a comprehensive analysis of existing research investigating the correlation between the intestinal microbiota and demyelinating diseases. Using advanced bibliometric tools such as VOSviewer and CiteSpace, this study analyzed the intricate relationship between the intestinal microbiota and the pathogenesis of demyelinating conditions. In addition, the study used literature statistical analysis to identify research hotspots and future directions in the field.
肠-脑轴（GBA）是一个连接中枢神经系统（CNS）和胃肠道系统的复杂双向通信网络。我们的研究旨在从文献计量学角度探讨肠道微生物群与脱髓鞘疾病之间的相关性，重点关注2014年以来的研究。
在科学网核心合集（WoSCC）上进行全面检索，以查找关于肠道微生物群与脱髓鞘疾病的研究，重点关注2014年1月1日至2024年3月29日发表的文献。我们使用VOSviewer、CiteSpace和Charticulator对数据进行可视化和分析。
我们收集了过去10年发表的429篇关于肠道微生物群与脱髓鞘疾病的学术文章。关于肠道微生物群与脱髓鞘疾病的研究频次随时间呈持续增长趋势。美国的出版物数量最多，而加拿大的平均被引次数最高，高达3429次，高于美国。此外，发表文章数量最多的期刊是《免疫学前沿》，有33篇文章和1494次引用。大多数研究者关注“多发性硬化症”和“肠道微生物群”，它们是肠道微生物群与脱髓鞘疾病领域的主要关键词。
本研究对现有关于肠道微生物群与脱髓鞘疾病相关性的研究进行了全面分析。本研究使用VOSviewer和CiteSpace等先进的文献计量工具，分析了肠道微生物群与脱髓鞘疾病发病机制之间的复杂关系。此外，该研究还利用文献统计分析确定了该领域的研究热点和未来方向。
