University of Witten/Herdecke, Germany.
Drug Discov Today. 2018 Feb;23(2):402-408. doi: 10.1016/j.drudis.2017.09.020. Epub 2017 Oct 6.
Drug repositioning is hot, and much development time and money can be spared if one selects an old drug and explores the efficacy and safety in a new indication. Phenytoin is studied and repositioned in many disorders after the initial indication epilepsy (from 1937). Its repositioning in depression was put in the spotlight by the Wall Street icon Jack Dreyfus, already in the 1970s. Innovations in the field of phenytoin still appear to be possible for a number of indications such as wound healing, bipolar disorder and aggression, and via a topical formulation for neuropathic pain. We will discuss wound healing and identified a number of critical issues related to its repositioning in this indication.
药物重新定位是热门话题，如果选择一种老药，并在新适应症中探索其疗效和安全性，可以节省大量的开发时间和资金。自 1937 年最初的适应症癫痫以来，人们一直在研究和重新定位苯妥英在许多疾病中的作用。20 世纪 70 年代，华尔街偶像杰克·德雷福斯（Jack Dreyfus）就将其在抑郁症中的重新定位推到了聚光灯下。在许多适应症，如伤口愈合、双相情感障碍和攻击性，以及治疗神经性疼痛的局部制剂方面，苯妥英仍有创新的可能。我们将讨论伤口愈合，并确定与该适应症药物重新定位相关的一些关键问题。
