基因表达在代谢相关脂肪性肝病和 COVID-19 结局中的调节作用。
Modulatory Roles of , , , and Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes.
机构信息
Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.
Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway.
出版信息
Viruses. 2024 Jun 19;16(6):985. doi: 10.3390/v16060985.
UNLABELLED
Metabolic-associated fatty liver disease (MAFLD) is a risk factor for severe COVID-19. This study explores the potential influence of gut hormone receptor and immune response gene expression on COVID-19 outcomes in MAFLD patients.
METHODS
We investigated gene expression levels of , , , and in patients with MAFLD and COVID-19 compared to controls. We examined associations between gene expression and clinical outcomes.
RESULTS
COVID-19 patients displayed altered expression, potentially impacting immune response and recovery. Downregulated in patients with MAFLD correlated with increased coagulation parameters. Elevated expression in patients with MAFLD was linked to specific immune cell populations and hospital stay duration. A significantly lower expression was observed in both MAFLD and severe COVID-19.
CONCLUSION
Our findings suggest potential modulatory roles for , , and in COVID-19 and MAFLD.
非酒精性脂肪性肝病（MAFLD）是严重 COVID-19 的一个风险因素。本研究旨在探讨肠激素受体和免疫反应基因表达对 MAFLD 患者 COVID-19 结局的潜在影响。
方法
我们比较了 MAFLD 合并 COVID-19 患者与对照组的、、、基因表达水平。我们还研究了基因表达与临床结局之间的相关性。
结果
COVID-19 患者的 表达发生改变，可能影响免疫反应和恢复。MAFLD 患者的 下调与凝血参数升高有关。MAFLD 患者的 表达升高与特定免疫细胞群和住院时间有关。在 MAFLD 和严重 COVID-19 患者中，均观察到 的表达显著降低。
结论
我们的研究结果表明、、和可能在 COVID-19 和 MAFLD 中具有调节作用。
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