晚餐至就寝时间间隔与2型糖尿病之间的关联：一项大规模横断面研究。
Association between dinner-bedtime interval and type 2 diabetes mellitus: a large-scale cross-sectional study.
作者信息
Wang Bingqian, Hou Jian, Mao Zhenxing, Chen Changying, Wang Chongjian, Yu Songcheng
机构信息
College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou City, 450001 People's Republic of China.
The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052 China.
出版信息
J Diabetes Metab Disord. 2024 Jan 3;23(1):1039-1045. doi: 10.1007/s40200-023-01382-3. eCollection 2024 Jun.
OBJECTIVE
Glucose metabolism is impacted by circadian disruption. Dinner-bedtime interval (DBI) was an accessible indicator to reflect the alignment between dinner time and circadian clock. We aimed to investigate the association of DBI with type 2 diabetes mellitus (T2DM).
METHODS
7676 adult subjects from the Henan Rural Cohort were included. Their demographic information including dinner time and bedtime was collected. Fasting venous blood samples were collected for biochemical determinations. Generalized linear regression model was used to analyze the factors influencing DBI. Furthermore, logistic regression incorporated with restricted cubic spline model was applied to evaluate the association between DBI and T2DM.
RESULTS
The results of multiple linear regression model showed that age (: -0.018, 95% : -0.021, -0.015) was negatively correlated with DBI. Female (: 0.311, 95% : 0.229, 0.393), junior high school education (: 0.246, 95% : 0.187, 0.306), high school education or above (: 0.346, 95% : 0.259, 0.433), average monthly income with 1000-1999 CNY(0.102, 95% CI: 0.032, 0.171), average monthly income ≥ 2000 CNY (: 0.164, 95% : 0.076, 0.251), moderate physical activity (: 0.134, 95% : 0.071, 0.197), current smokers (: 0.214, 95% : 0.118, 0.309), current drinkers (: 0.099, 95% : 0.008, 0.190) were positively correlated with DBI. Furthermore, DBI was significantly associated with T2DM (adjusted : 0.910, 95%: 0.845-0.979, = 0.012). DBI longer than 3 h was associated with decreased risk of T2DM (adjusted : 0.773, 95%: 0.648-0.921, = 0.004).
CONCLUSIONS
DBI larger than 3 h is beneficial to T2DM prevention. Further investigation is required to verify the association.
目的
昼夜节律紊乱会影响葡萄糖代谢。晚餐至就寝时间间隔（DBI）是反映晚餐时间与昼夜节律时钟一致性的一个可获取指标。我们旨在研究DBI与2型糖尿病（T2DM）之间的关联。
方法
纳入了来自河南农村队列的7676名成年受试者。收集了他们的人口统计学信息，包括晚餐时间和就寝时间。采集空腹静脉血样进行生化测定。使用广义线性回归模型分析影响DBI的因素。此外，应用结合受限立方样条模型的逻辑回归来评估DBI与T2DM之间的关联。
结果
多元线性回归模型结果显示，年龄（β：-0.018，95%置信区间：-0.021，-0.015）与DBI呈负相关。女性（β：0.311，95%置信区间：0.229，0.393）、初中文化程度（β：0.246，95%置信区间：0.187，0.306）、高中及以上文化程度（β：0.346，95%置信区间：0.259，0.433）、月平均收入1000 - 1999元（β：0.102，95%置信区间：0.032，0.171）、月平均收入≥2000元（β：0.164，95%置信区间：0.076，0.251）、中等体力活动（β：0.134，95%置信区间：0.071，0.197）、当前吸烟者（β：0.214，95%置信区间：0.118，0.309）、当前饮酒者（β：0.099，95%置信区间：0.008，0.190）与DBI呈正相关。此外，DBI与T2DM显著相关（调整后β：0.910，95%置信区间：0.845 - 0.979，P = 0.012）。DBI超过3小时与T2DM风险降低相关（调整后β：0.773，95%置信区间：0.648 - 0.921，P = 0.004）。
结论
DBI大于3小时有利于预防T2DM。需要进一步研究来验证这种关联。
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