Waugh M A, Cooke E M, Nehaul B B, Brayson J
Br J Vener Dis. 1979 Dec;55(6):411-4. doi: 10.1136/sti.55.6.411.
A prospective, randomised, single-blind trial was carried out to compare the efficacy and tolerability of minocycline and ampicillin in the treatment of gonorrhoea in men. One hundred and twenty men were treated with minocycline 300 mg and 121 men with ampicillin 2 g and probenecid 1 g. Cure rates were similar in both groups of patients. There were few side effects. Of 135 strains of Neisseria gonorrhoeae tested to different concentrations of minocycline and penicillin, two were resistant to penicillin (minimum inhibitory concentration (MIC) greater than or equal to 0.1 microgram/ml) and seven to minocycline (MIC greater than 1.0 microgram/ml). The incidence of PGU was 31% in those patients treated with minocycline and 34% in those treated with ampicillin plus probenecid, the difference not being statistically significant. PGU occurred more often after treatment with minocycline than in previous studies.
进行了一项前瞻性、随机、单盲试验，以比较米诺环素和氨苄西林治疗男性淋病的疗效和耐受性。120名男性接受300毫克米诺环素治疗，121名男性接受2克氨苄西林和1克丙磺舒治疗。两组患者的治愈率相似。副作用很少。对135株淋病奈瑟菌进行不同浓度米诺环素和青霉素测试，其中两株对青霉素耐药（最低抑菌浓度（MIC）大于或等于0.1微克/毫升），七株对米诺环素耐药（MIC大于1.0微克/毫升）。接受米诺环素治疗的患者中，尿道炎后综合征（PGU）的发生率为31%，接受氨苄西林加丙磺舒治疗的患者中为34%，差异无统计学意义。与之前的研究相比，米诺环素治疗后PGU的发生率更高。
