Center for Research in Health Sciences, Biological and Health Sciences Center, University of Northern Paraná, Rua Marselha, 591, Jardim Piza, Londrina, Paraná State, 86041-140, Brazil.
Department of Pathology, Biological Sciences Center, Londrina State University, Londrina, Paraná State, 86057-970, Brazil.
Eur J Appl Physiol. 2023 Sep;123(9):1949-1964. doi: 10.1007/s00421-023-05207-2. Epub 2023 Apr 29.
Delayed-onset muscle soreness (DOMS) describes an entity characterized by ultrastructural muscle damage. Hesperidin methyl chalcone (HMC) is a synthetic flavonoid presenting analgesic, anti-inflammatory, and antioxidant properties. We evaluated the effects of HMC upon DOMS.
In a preventive paradigm, 31 sedentary young men were submitted to a randomized, double-blinded parallel trial and received HMC 500 mg or one placebo capsule × 3 days before an intense dynamic exercise protocol (concentric/eccentric actions) applied for lower limbs for inducing muscle damage. Assessments were conducted at baseline, and 24 and 48 h after, comprising physical performance, and post-muscle soreness and damage, inflammation, recovery of muscle strength, and postural balance associated with DOMS. HMC safety was also evaluated. Thirty participants completed the study.
HMC improved the performance of participants during exercise (40.3 vs 51.3 repetitions to failure, p = 0.0187) and inhibited CPK levels (90.5 vs 57.9 U/L, p = 0.0391) and muscle soreness during passive quadriceps palpation (2.6 vs 1.4 VAS cm, p = 0.0439), but not during active actions, nor did it inhibit IL-1β or IL-10 levels. HMC improved muscle strength recovery, and satisfactorily refined postural balance, without inducing injury to kidneys or liver.
Preemptive HMC supplementation may be beneficial for boosting physical performance and for the amelioration of clinical parameters related to DOMS, including pain on muscle palpation, increased blood CPK levels, and muscle strength and proprioceptive deficits, without causing adverse effects. These data advance the understanding of the benefits provided by HMC for DOMS treatment, which supports its usefulness for such purpose.
延迟性肌肉酸痛（DOMS）描述了一种以超微结构肌肉损伤为特征的实体。橙皮苷甲查尔酮（HMC）是一种具有镇痛、抗炎和抗氧化特性的合成类黄酮。我们评估了 HMC 对 DOMS 的影响。
在预防范式中，31 名久坐的年轻男性被随机分为双盲平行试验组，在进行下肢剧烈动态运动方案（向心/离心运动）之前的 3 天内，每天接受 HMC 500mg 或安慰剂胶囊×3 次，以诱导肌肉损伤。在基线、24 小时和 48 小时后进行评估，包括身体表现以及与 DOMS 相关的肌肉酸痛和损伤后、炎症、肌肉力量恢复和姿势平衡。还评估了 HMC 的安全性。30 名参与者完成了研究。
HMC 改善了参与者在运动中的表现（40.3 次与 51.3 次失败，p=0.0187）和 CPK 水平（90.5 与 57.9 U/L，p=0.0391）以及股四头肌被动触诊时的肌肉酸痛（2.6 与 1.4 VAS cm，p=0.0439），但在主动运动中没有抑制作用，也没有抑制 IL-1β 或 IL-10 水平。HMC 改善了肌肉力量恢复，并且令人满意地改善了姿势平衡，而不会引起肾脏或肝脏损伤。
预防性 HMC 补充可能有益于提高身体表现，改善与 DOMS 相关的临床参数，包括肌肉触诊时的疼痛、CPK 水平升高、肌肉力量和本体感觉缺陷，而不会引起不良反应。这些数据加深了对 HMC 治疗 DOMS 益处的理解，支持了其在这方面的有用性。
