Malekinejad Hassan, Alenabi Aylar, Fink-Gremmels Johanna
Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, 5715799313 Urmia, Iran.
Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, 5756151818 Urmia, Iran.
Front Biosci (Elite Ed). 2024 May 7;16(2):12. doi: 10.31083/j.fbe1602012.
Fungi are a large group of eukaryotic microorganisms that can readily adapt to diverse environments and occur in almost all climatic zones and continents. Although some fungi are inevitable in the environment for the decay and recycling of organic material, many species are known to produce secondary metabolites, and these mycotoxins, when ingested with food or feed materials, can adversely affect animal and human health. Among the toxigenic fungi, species are recognized as so-called field fungi, invading crops and producing mycotoxins predominantly before harvest. produces a wide array of mycotoxins, causing different plant diseases. Fusariosis causes significant economic losses in a wide range of crops. secondary metabolites, particularly trichothecenes, are potent toxins in mammalian species and cause diverse adverse effects in humans and animals. Other prominent toxins with entirely different chemical structures are zearalenone and its derivatives and fumonisins. With an entirely different life cycle, toxins of endophytes belonging to the genus Epichloë and and comprise an animal health risk, particularly for grazing animals. This review aimed to summarize the adverse effects of selected and toxins, with a special emphasis on their occurrence in roughages and their mechanisms of action, and describe their effect on animal health and welfare and the potentially related public health risks.
真菌是一大类真核微生物,能够很容易地适应各种环境,几乎出现在所有气候带和各大洲。虽然环境中有些真菌对于有机物质的腐烂和循环是不可避免的,但许多真菌物种已知会产生次生代谢产物,而这些霉菌毒素在与食物或饲料一起被摄入时,会对动物和人类健康产生不利影响。在产毒真菌中,有些物种被认为是所谓的田间真菌,它们侵入作物并主要在收获前产生霉菌毒素。(此处原文缺失具体物种名)会产生各种各样的霉菌毒素,引发不同的植物病害。镰刀菌病在多种作物中造成重大经济损失。(此处原文缺失具体物种名)的次生代谢产物,特别是单端孢霉烯族毒素,是哺乳动物物种中的强效毒素,会对人类和动物造成各种不利影响。其他具有完全不同化学结构的重要毒素是玉米赤霉烯酮及其衍生物和伏马毒素。属于内生真菌属(此处原文缺失具体属名)的内生菌毒素具有完全不同的生命周期,构成动物健康风险,特别是对放牧动物而言。本综述旨在总结所选(此处原文缺失具体物种名)和(此处原文缺失具体物种名)毒素的不利影响,特别强调它们在粗饲料中的存在情况及其作用机制,并描述它们对动物健康和福利的影响以及潜在的相关公共卫生风险。