遗传和环境对节制饮食行为的影响。
Genetic and environmental influences on restrained eating behavior.
机构信息
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
出版信息
Int J Eat Disord. 2009 Dec;42(8):765-72. doi: 10.1002/eat.20734.
OBJECTIVE
We examined the relative contributions of genetic and environmental influences to restrained eating.
METHOD
Restrained eating was assessed by the Restraint Scale in a survey mailed to all twins enrolled in the University of Washington Twin Registry. We used structural equation modeling to estimate genetic and nongenetic contributions to restrained eating.
RESULTS
1,196 monozygotic (MZ), 456 same-sex dizygotic (DZ) twins, and 447 opposite-sex twins were included in analyses. Restraint Scale scores were more closely correlated in MZ twins (r(male) = .55, r(female) = .55) than in same-sex DZ twins (r(male) = .31, r(female) = .19). Based on structural equation modeling, the estimated heritability for restrained eating, adjusted for body mass index (BMI) and sex, was 43% (95% confidence interval 35-50%). There was little evidence for common environmental effects.
DISCUSSION
These results indicate an inherited component to restrained eating. Genes could influence restrained eating directly or through inherited mediators such as personality factors or tendencies to gain weight.
目的
我们研究了遗传和环境因素对节食行为的相对贡献。
方法
通过邮寄给华盛顿大学双胞胎登记处所有双胞胎的调查问卷，用节食量表评估节食行为。我们采用结构方程模型来估计节食行为的遗传和非遗传因素。
结果
在分析中纳入了 1196 对同卵（MZ）双胞胎、456 对同性别异卵（DZ）双胞胎和 447 对异性别双胞胎。MZ 双胞胎的节食量表评分相关性更高（男性 r =.55，女性 r =.55），而同性别的 DZ 双胞胎的相关性更低（男性 r =.31，女性 r =.19）。基于结构方程模型，调整体重指数（BMI）和性别后，节食行为的遗传度估计值为 43%（95%置信区间 35-50%）。共同环境影响的证据很少。
讨论
这些结果表明节食行为存在遗传成分。基因可能通过直接影响或通过遗传中介，如人格因素或增重倾向，来影响节食行为。
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