Comprehensive Epilepsy Center, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Curr Neurol Neurosci Rep. 2024 Aug;24(8):303-314. doi: 10.1007/s11910-024-01350-1. Epub 2024 Jun 28.
The burden of epilepsy is complex and consists of elements directly related to acute seizures as well as those associated with living with a chronic neurologic disorder. The purpose of this systematic review was to characterize short-term burdens of seizures and to explore the potential value of acute treatments to mitigate these burdens apart from reducing the risk of status epilepticus.
A systematic literature search was conducted using PubMed to identify articles published from January 1, 2017, to June 22, 2023, that described short-term burdens and acute treatments of seizures. Primary outcomes included those related to short-term burdens of seizures and the benefits of acute treatments to reduce short-term burdens. Of the 1332 articles identified through PubMed and 17 through other sources, 27 had relevant outcomes and were included in the qualitative synthesis. Seizure emergencies negatively affected short-term quality of life and the ability to conduct normal daily living activities and were associated with physical (injury) and financial (emergency transport, hospitalization) burdens. The use of acute treatment was associated with a rapid return (≤ 1 h) to normal function/self for both patients and caregivers and potentially lower healthcare utilization and costs. Seizure action plans may improve knowledge and comfort with seizure care, empowering patients and caregivers. The short-term burden of seizures can create a substantial negative impact on patients and caregivers. Acute treatments may reduce the short-term burdens of seizures in addition to their well-described role to reduce seizure activity and the risk for status epilepticus.
癫痫的负担是复杂的，包括与急性发作直接相关的因素以及与慢性神经疾病相关的因素。本系统综述的目的是描述癫痫发作的短期负担，并探讨急性治疗减轻这些负担的潜在价值，而不仅仅是降低癫痫持续状态的风险。
使用 PubMed 进行了系统文献检索，以确定 2017 年 1 月 1 日至 2023 年 6 月 22 日期间发表的描述癫痫发作短期负担和急性治疗的文章。主要结果包括与癫痫发作短期负担相关的结果以及急性治疗减轻短期负担的益处。通过 PubMed 确定了 1332 篇文章和其他来源的 17 篇文章，其中 27 篇具有相关结果，并纳入定性综合分析。癫痫发作急症会对短期生活质量和进行正常日常生活活动的能力产生负面影响，并与身体（伤害）和经济（紧急运输、住院）负担有关。急性治疗的使用与患者和护理人员的正常功能/自我恢复（≤1 小时）相关，并且可能降低医疗保健的利用和成本。癫痫发作行动计划可能会提高患者和护理人员对癫痫护理的了解和舒适度，赋予他们权力。癫痫发作的短期负担会对患者和护理人员造成巨大的负面影响。急性治疗除了其减轻癫痫发作活动和癫痫持续状态风险的明确作用外，还可能减轻癫痫发作的短期负担。
