Ferrara Louisa, Kamity Ranjith, Htun Zeyar, Dumpa Vikramaditya, Islam Shahidul, Hanna Nazeeh
Division of Neonatology, Department of Pediatrics, NYU Langone Hospital - Long Island, NYU Grossman Long Island School of Medicine, Mineola, NY, 11501, USA.
Division of Neonatology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR 72205.
Res Sq. 2024 Jun 18:rs.3.rs-4504972. doi: 10.21203/rs.3.rs-4504972/v1.
Premature infants frequently face feeding challenges due to disrupted coordination of sucking, swallowing, and breathing, increasing their risk of dysphagia. There are few effective treatment options available for these infants. In adults experiencing dysphagia, consuming cold foods or liquids can be an effective strategy. This method stimulates the sensory receptors in the pharyngeal mucosa, promoting safer and more effective swallowing. We have previously demonstrated that short-duration feeding (5 swallows) with cold liquid significantly reduces dysphagia in preterm infants; however, the impact of extended cold milk feeding remains unexplored. This study aims to assess the safety of cold milk feedings in preterm infants diagnosed with uncoordinated feeding patterns and its effect on feeding performance.
Preterm infants with uncoordinated feeding patterns (n=26) were randomized to be fed milk at either room or cold temperatures using an experimental, randomized crossover design. We monitored axillary and gastric content temperatures, mesenteric blood flow, and feeding performance.
The findings suggest that preterm infants can safely tolerate cold milk without any clinically significant changes in temperature or mesenteric blood flow, and it may enhance certain aspects of feeding performance.
These results suggest that cold milk feeding could be a safe therapeutic option for preterm infants. These results highlight the potential for further comprehensive studies to explore the use of cold milk as an effective therapeutic approach for addressing feeding and swallowing difficulties in preterm infants. Registered at clinicaltrials.org #NCT04421482.
由于吸吮、吞咽和呼吸协调紊乱，早产儿经常面临喂养挑战，增加了吞咽困难的风险。针对这些婴儿的有效治疗选择很少。在吞咽困难的成年人中，食用冷食或冷饮可能是一种有效的策略。这种方法刺激咽黏膜中的感觉受体，促进更安全、更有效的吞咽。我们之前已经证明，用冷液体进行短时间喂养（5次吞咽）可显著降低早产儿的吞咽困难；然而，延长冷牛奶喂养的影响仍未得到探索。本研究旨在评估冷牛奶喂养对诊断为喂养模式不协调的早产儿的安全性及其对喂养表现的影响。
采用实验性随机交叉设计，将26名喂养模式不协调的早产儿随机分为两组，分别用室温水或冷牛奶喂养。我们监测了腋窝和胃内容物温度、肠系膜血流和喂养表现。
研究结果表明，早产儿能够安全耐受冷牛奶，体温或肠系膜血流没有任何临床上的显著变化，并且冷牛奶喂养可能会改善喂养表现的某些方面。
这些结果表明，冷牛奶喂养可能是早产儿一种安全的治疗选择。这些结果凸显了进一步开展全面研究的潜力，以探索将冷牛奶作为解决早产儿喂养和吞咽困难的有效治疗方法。在clinicaltrials.org上注册，注册号为#NCT04421482。
