Gajda Anna, Szymanek-Bany Iwona, Nowacka-Kozak Ewelina, Gbylik-Sikorska Małgorzata
Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Puławy, Poland.
J Vet Res. 2024 May 29;68(2):255-261. doi: 10.2478/jvetres-2024-0030. eCollection 2024 Jun.
Chicken bones, a by-product of the poultry industry, can directly or indirectly enter the food chain. Bone meal and bone products could be sources of many contaminants. Considering the wide range of uses made of bones in the culinary and food industries, this material needs to be safe and antibiotic residue-free. To determine if such is the case, the concentration of doxycycline in chicken bones was investigated, this antimicrobial being one of the most commonly used in poultry production.
Ross 308 broilers were grouped into three experimental and one control group. Doxycycline was administered in drinking water at therapeutic and sub-therapeutic doses, as well as spray treatment. The concentration of doxycycline in bones was determined post slaughter by ultra-high performance liquid chromatography-tandem mass spectrometry.
Doxycycline was quantified at 135 μg/kg 22 days after the last day of antibiotic administration at therapeutic doses; 2,285 μg/kg after sub-therapeutic treatment for 27 days and 9.62 μg/kg 22 days after the end of spray application.
High concentrations and long persistence of doxycycline in bones were found in this study. Doxycycline can contaminate all bone-derived products in the food and fertiliser industries.
鸡骨是家禽业的副产品，可直接或间接进入食物链。骨粉和骨制品可能是多种污染物的来源。鉴于骨头在烹饪和食品工业中的广泛用途，这种材料需要安全且无抗生素残留。为了确定情况是否如此，对鸡骨中强力霉素的浓度进行了调查，这种抗菌药物是家禽生产中最常用的药物之一。
将罗斯308肉鸡分为三个实验组和一个对照组。通过饮用水以治疗剂量和亚治疗剂量给予强力霉素，并进行喷雾处理。屠宰后通过超高效液相色谱-串联质谱法测定骨头中强力霉素的浓度。
在治疗剂量下最后一次给药后22天，骨头中强力霉素的定量为135μg/kg；亚治疗处理27天后为2285μg/kg，喷雾应用结束后22天为9.62μg/kg。
本研究发现骨头中强力霉素浓度高且残留时间长。强力霉素会污染食品和肥料行业中所有源自骨头的产品。
