Jansén C T
Photodermatol. 1985 Jun;2(3):166-9.
During 3 consecutive summers, patients from a total group of 40 persons with polymorphous light eruptions (PMLE) participated in a randomized, double-blind, cross-over study comparing the sun-protective effect of placebo capsules, a chloroquine derivative (200 mg daily of oxychloroquine), and a carotenoid preparation (betacarotene and canthaxanthine in a daily total dose of 100 mg). A total of 35 carotenoid, 38 chloroquine, and 27 placebo treatment periods were registered. Full freedom from sun sensitivity was obtained during 6 carotenoid and 8 chloroquine periods, but never with placebo treatment. In addition, a partial sun tolerance was induced in 17 carotenoid periods, 15 chloroquine periods, and in 14 placebo treatment periods.
在连续3个夏天期间，来自总共40名多形性日光疹（PMLE）患者参与了一项随机、双盲、交叉研究，比较了安慰剂胶囊、一种氯喹衍生物（每日200毫克羟氯喹）和一种类胡萝卜素制剂（β-胡萝卜素和角黄素，每日总剂量100毫克）的防晒效果。总共记录了35个类胡萝卜素治疗期、38个氯喹治疗期和27个安慰剂治疗期。在6个类胡萝卜素治疗期和8个氯喹治疗期实现了完全无日光敏感性，但安慰剂治疗从未达到此效果。此外，在17个类胡萝卜素治疗期、15个氯喹治疗期和14个安慰剂治疗期诱导出了部分日光耐受性。
