Suhonen R, Plosila M
Dermatologica. 1981;163(2):172-6. doi: 10.1159/000250156.
50 patients with polymorphous light eruptions with treated with a beta-carotene-canthaxanthin combination, Ro 8-8427 (Phenoro) at a daily dose of 100 mg or placebo for a duration of 10 weeks in a double-blind, randomized, cross-over trial. The effect of treatment was evaluated clinically on the basis of occurrence of pruritus, erythema and eruptions as well as subjectively through the patients own opinion about the condition of their skin. Excellent results after treatment with Ro 8-8427 were achieved in 27 cases and good results in 9, regardless of whether this preparation was the first treatment or the second. The corresponding figures after placebo were 16 and 12, respectively. Similarly, moderate results were achieved in 6 cases after Ro 8-8427 and in 9 cases after placebo. Poor results were achieved in only 3 cases after R0 8-8427 as compared with 8 after placebo. Only a few, mild side effects were observed during the treatment periods.
在一项双盲、随机、交叉试验中，50例多形性日光疹患者接受了β-胡萝卜素-角黄素组合制剂Ro 8-8427（Phenoro）治疗，每日剂量为100毫克，或接受安慰剂治疗，为期10周。治疗效果通过瘙痒、红斑和皮疹的出现情况进行临床评估，并通过患者对自身皮肤状况的主观评价来评估。无论Ro 8-8427是首次治疗还是第二次治疗，治疗后27例取得了优异效果，9例取得了良好效果。安慰剂组相应的数字分别为16例和12例。同样，Ro 8-8427治疗后6例取得了中等效果，安慰剂治疗后9例取得了中等效果。Ro 8-8427治疗后仅有3例效果不佳，而安慰剂组为8例。治疗期间仅观察到少数轻微的副作用。
