Deng Ying, Wang Duo, Zhao Wenhua, Qiu Guanhua, Zhu Xiaoqi, Wang Qin, Qin Tian, Tang Jiali, Jiang Jinghang, Lin Ningjing, Wei Lili, Liu Yichen, Xie Yuan, Chen Jie, Deng Liu, Liu Junjie
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, China.
Research (Wash D C). 2024 Jul 1;7:0397. doi: 10.34133/research.0397. eCollection 2024.
Hyperthermia therapy is considered an effective anticancer strategy. However, high temperature can trigger an excessive inflammatory response, leading to tumor self-protection, immunosuppression, metastasis, and recurrence. To address this issue, we reported a multifunctional photothermal nanoplatform to achieve mild hyperthermia photothermal therapy (mild PTT) based on cisplatin (DDP) and a ferrocene metal-organic framework (MOF-Fc) nanocomposite, which can specifically enhance ferroptosis-triggered oxidative stress levels and synchronously amplify mild hyperthermia PTT-mediated anticancer responses. Both in vitro and in vivo antineoplastic results verify the superiority of mild PTT with DDP/MOF-Fc@HA. The combination of DDP and MOF-Fc exhibits Fenton catalytic activity and glutathione depletion capacity, magnifying mild hyperthermia effects via the radical oxygen species (ROS)-adenosine triphosphate (ATP)-HSP silencing pathway, with important implications for clinical hyperthermia therapy.
热疗被认为是一种有效的抗癌策略。然而，高温会引发过度的炎症反应，导致肿瘤自我保护、免疫抑制、转移和复发。为了解决这个问题，我们报道了一种基于顺铂（DDP）和二茂铁金属有机框架（MOF-Fc）纳米复合材料的多功能光热纳米平台，以实现温和热光热疗法（温和PTT），该平台可以特异性提高铁死亡引发的氧化应激水平，并同步放大温和热PTT介导的抗癌反应。体外和体内抗肿瘤结果均证实了DDP/MOF-Fc@HA温和PTT的优越性。DDP和MOF-Fc的组合表现出芬顿催化活性和谷胱甘肽消耗能力，通过活性氧（ROS）-三磷酸腺苷（ATP）-热休克蛋白沉默途径放大温和热疗效果，对临床热疗具有重要意义。
