State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
School of Applied Chemistry and Engineering, University of Sciences and Technology of China, Hefei, 230026, P. R. China.
Angew Chem Int Ed Engl. 2021 Jun 1;60(23):12971-12979. doi: 10.1002/anie.202101924. Epub 2021 Apr 28.
Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia is easily repaired by stress-induced heat shock proteins (HSPs). Thus, maximizing the PTT efficiency and minimizing the damage to healthy tissues simultaneously by adopting appropriate therapeutic temperatures is imperative. Herein, an innovative strategy is reported: ferroptosis-boosted mild PTT based on a single-atom nanozyme (SAzyme). The Pd SAzyme with atom-economical utilization of catalytic centers exhibits peroxidase (POD) and glutathione oxidase (GSHOx) mimicking activities, and photothermal conversion performance, which can result in ferroptosis featuring the up-regulation of lipid peroxides (LPO) and reactive oxygen species (ROS). The accumulation of LPO and ROS provides a powerful approach for cleaving HSPs, which enables Pd SAzyme-mediated mild-temperature PTT.
光热疗法（PTT）是一种极具前途的肿瘤治疗方式。然而，过多的热量不可避免地会损伤肿瘤附近的正常组织，而轻度热疗引起的应激诱导热休克蛋白（HSPs）很容易修复癌细胞的损伤。因此，通过采用适当的治疗温度，同时最大限度地提高 PTT 效率并最小化对健康组织的损伤至关重要。在这里，报道了一种创新策略：基于单原子纳米酶（SAzyme）的铁死亡增强型温和 PTT。Pd SAzyme 具有原子经济性利用催化中心的过氧化物酶（POD）和谷胱甘肽氧化酶（GSHOx）模拟活性以及光热转换性能，可导致脂质过氧化物（LPO）和活性氧（ROS）上调的铁死亡。LPO 和 ROS 的积累为切割 HSPs 提供了一种强大的方法，这使得 Pd SAzyme 介导的温和温度 PTT 成为可能。
