压疮的局部治疗。Varidase与氧化锌的随机对照试验。

Topical treatment of pressure ulcers. A randomized comparative trial of Varidase and zinc oxide.

作者信息

Agren M S, Strömberg H E

出版信息

Scand J Plast Reconstr Surg. 1985;19(1):97-100. doi: 10.3109/02844318509052871.

Abstract

In a single-blind, randomized trial, the efficacy of topical streptokinase-streptodornase (Varidase) solution was compared with that of zinc oxide on necrotic pressure ulcers in 28 patients. The effectiveness was determined by measuring the necrosis removal within 8 weeks. This occurred in 6 patients (43%) treated with Varidase and in 7 (50%) treated with zinc oxide. The statistical tests applied showed no significant difference between the two treatments despite the use of a high power (1-beta = 0.95). The data suggest that the two regimens are about equally effective in the treatment of necrotic tissue.

摘要

在一项单盲随机试验中，对28例坏死性压疮患者比较了局部用链激酶-链道酶（Varidase）溶液与氧化锌的疗效。通过测量8周内坏死组织的清除情况来确定疗效。接受Varidase治疗的6例患者（43%）和接受氧化锌治疗的7例患者（50%）出现了坏死组织清除。尽管使用了较高的检验效能（1-β=0.95），但应用的统计学检验显示两种治疗方法之间无显著差异。数据表明，两种治疗方案在治疗坏死组织方面的效果大致相同。