School of Medicine, Jiangsu University, Zhenjiang 212013, China; Yixing Hospital Affiliated to Jiangsu University, Yixing 214200, China.
Yixing Hospital Affiliated to Jiangsu University, Yixing 214200, China.
Ageing Res Rev. 2024 Aug;99:102399. doi: 10.1016/j.arr.2024.102399. Epub 2024 Jun 30.
Helicobacter pylori, a type of gram-negative bacterium, infects roughly half of the global population. It is strongly associated with gastrointestinal disorders like gastric cancer, peptic ulcers, and chronic gastritis. Moreover, numerous studies have linked this bacterium to various extra-gastric conditions, including hematologic, cardiovascular, and neurological issues. Specifically, research has shown that Helicobacter pylori interacts with the brain through the microbiota-gut-brain axis, thereby increasing the risk of neurological disorders. The inflammatory mediators released by Helicobacter pylori-induced chronic gastritis may disrupt the function of the blood-brain barrier by interfering with the transmission or direct action of neurotransmitters. This article examines the correlation between Helicobacter pylori and a range of conditions, such as hyperhomocysteinemia, schizophrenia, Alzheimer's disease, Parkinson's disease, ischemic stroke, multiple sclerosis, migraine, and Guillain-Barré syndrome.
幽门螺杆菌是一种革兰氏阴性菌，感染了大约全球一半的人口。它与胃癌、消化性溃疡和慢性胃炎等胃肠道疾病密切相关。此外，许多研究还将这种细菌与各种胃外疾病联系起来，包括血液、心血管和神经系统问题。具体来说，研究表明，幽门螺杆菌通过微生物群-肠道-大脑轴与大脑相互作用，从而增加了神经紊乱的风险。幽门螺杆菌引起的慢性胃炎释放的炎症介质可能通过干扰神经递质的传递或直接作用来破坏血脑屏障的功能。本文研究了幽门螺杆菌与一系列疾病的相关性，如高同型半胱氨酸血症、精神分裂症、阿尔茨海默病、帕金森病、缺血性中风、多发性硬化症、偏头痛和吉兰-巴雷综合征。
