Department of Endocrinology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Clin Invest Med. 2024 Jun;47(2):23-39. doi: 10.3138/cim-2024-2744.
Over the past 20 years, much of the research on diabetes has focused on pancreatic beta cells. In the last 10 years, interest in the important role of pancreatic alpha cells in the pathogenesis of diabetes, which had previously received little attention, has grown. We aimed to summarize and visualize the hotspot and development trends of pancreatic alpha cells through bibliometric analysis and to provide research direction and future ideas for the treatment of diabetes and other islet-related diseases.
We used two scientometric software packages (CiteSpace 6.1.R6 and VOSviewer1.6.18) to visualize the information and connection of countries, institutions, authors, and keywords in this field.
A total of 532 publications, published in 752 institutions in 46 countries and regions, were included in this analysis. The United States showed the highest output, accounting for 39.3% of the total number of published papers. The most active institution was Vanderbilt University, and the authors with highest productivity came from Ulster University. In recent years, research hotspots have concentrated on transdifferentiation, gene expression, and GLP-1 regulatory function. Visualization analysis shows that research hotspots mainly focus on clinical diseases as well as physiological and pathological mechanisms and related biochemical indicators.
This study provides a review and summary of the literature on pancreatic alpha cells through bibliometric and visual methods and shows research hotspot and development trends, which can guide future directions for research.
在过去的 20 年里，大量的糖尿病研究集中在胰腺β细胞上。在过去的 10 年里，以前很少关注的胰腺α细胞在糖尿病发病机制中的重要作用引起了人们的兴趣。我们旨在通过文献计量分析总结和可视化胰腺α细胞的热点和发展趋势，并为糖尿病和其他胰岛相关疾病的治疗提供研究方向和未来思路。
我们使用了两种科学计量学软件包（CiteSpace 6.1.R6 和 VOSviewer1.6.18）来可视化该领域国家、机构、作者和关键词的信息和联系。
共纳入 532 篇文献，发表于 46 个国家和地区的 752 个机构。美国的发文量最高，占总发文量的 39.3%。最活跃的机构是范德比尔特大学，最高产的作者来自阿尔斯特大学。近年来，研究热点集中在转分化、基因表达和 GLP-1 调节功能上。可视化分析表明，研究热点主要集中在临床疾病以及生理和病理机制及相关生化指标上。
本研究通过文献计量学和可视化方法对胰腺α细胞的文献进行了综述和总结，展示了研究热点和发展趋势，为未来的研究方向提供了指导。
