遗传风险、生活方式及其与肥胖和肥胖相关疾病的相互作用与肥胖和肥胖相关疾病的关系。

Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities.

机构信息

Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06355, Republic of Korea; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.

Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell Metab. 2024 Jul 2;36(7):1494-1503.e3. doi: 10.1016/j.cmet.2024.06.004.

DOI:10.1016/j.cmet.2024.06.004

PMID:38959863

Abstract

The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity and obesity-related morbidities remains unknown. We explored how the interaction between genetic and lifestyle factors influences the risk of obesity and obesity-related morbidities. The polygenic score for body mass index was calculated to quantify inherited susceptibility to obesity in 338,645 UK Biobank European participants, and a composite lifestyle score was derived from five obesogenic factors (physical activity, diet, sedentary behavior, alcohol consumption, and sleep duration). We observed significant interaction between high genetic risk and poor lifestyles (p < 0.001). Absolute differences in obesity risk between those who adhere to healthy lifestyles and those who do not had gradually expanded with an increase in polygenic score. Despite a high genetic risk for obesity, individuals can prevent obesity-related morbidities by adhering to a healthy lifestyle and maintaining a normal body weight. Healthy lifestyles should be promoted irrespective of genetic background.

摘要

遗传因素和生活方式因素的相互作用如何影响肥胖和肥胖相关疾病的风险尚不清楚。我们探讨了遗传因素和生活方式因素的相互作用如何影响肥胖和肥胖相关疾病的风险。在 338645 名英国生物银行欧洲参与者中，通过计算体重指数的多基因评分来量化肥胖的遗传易感性，从五个肥胖因素（身体活动、饮食、久坐行为、饮酒和睡眠时间）得出综合生活方式评分。我们观察到遗传风险高和生活方式差之间存在显著的相互作用（p<0.001）。在遵循健康生活方式的人和不遵循健康生活方式的人之间，肥胖风险的绝对差异随着多基因评分的增加而逐渐扩大。尽管肥胖的遗传风险很高，但通过遵循健康的生活方式和保持正常的体重，个体可以预防肥胖相关的疾病。无论遗传背景如何，都应提倡健康的生活方式。