Al Musayeib Nawal M, Amina Musarat, Maqsood Farah, Bokhary Kholoud A, Alrashidi Nada S
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
Department of Optometry and Vision Science, College of Applied Medical Science, King Saud University, Riyadh 11451, Saudi Arabia.
Bioinorg Chem Appl. 2024 Jun 6;2024:8180102. doi: 10.1155/2024/8180102. eCollection 2024.
Magnesium oxide nanoparticles (MgONPs) have been fabricated by several approaches, including green chemistry approach due to diverse application and versatile features.
The current study aimed to prepare a convenient, biocompatible, and economically viable MgONPs using waste citron peel extract (CP-MgONPs) to evaluate their biological applications.
The CP-MgONPs were synthesized by a sustainable approach from extract of waste citron peel both as capping and reducing agents without use of any hazardous material. The physicochemical features of formed CP-MgONPs were determined by sophisticated analytical and microscopic techniques. The biogenic CP-MgONPs were examined for their antibacterial, anticarcinogenic, and photocatalytic attributes.
A prominent absorption peak in the UV-Vis spectra at 284 nm was the distinguishing characteristic of the CP-MgONPs. The scanning electron microscopy (SEM) reveals polyhedral morphology of nanoparticles with slight agglomeration of CP-MgONPs. The CP-MgONPs exerted excellent antibacterial potencies against six bacterial strains. The CP-MgONPs displayed significant susceptibility towards (20.72 ± 0.33 mm) and (19.52 ± 0.05 mm) with the highest inhibition zones. The anticancer effect of CP-MgONPs was evaluated against HepG2 (IC : 15.3 g·mL) cancer cells and exhibited potential anticancer activity. A prompt inversion of cellular injury manifested as impairment of the integrity of the cell membrane, apoptosis, and oxidative stress was observed in treated cells with CP-MgONPs. The biosynthesized CP-MgONPs also conducted successful photocatalytic potential as much as MgO powder under the UV-light using acid orange 8 (AO-8) dye. The degradation performance of CP-MgONPs showed over 94% photocatalytic degradation efficiency of acid orange 8 (AO-8) dyes within a short time.
Outcomes of this research signify that biogenic CP-MgONPs may be advantageous at low concentrations, with positive environmental impacts.
氧化镁纳米颗粒（MgONPs）已通过多种方法制备，包括绿色化学方法，因其具有多种应用和多功能特性。
本研究旨在利用废弃香橼皮提取物制备一种便捷、生物相容且经济可行的MgONPs（CP-MgONPs），并评估其生物学应用。
采用可持续方法，以废弃香橼皮提取物作为封端剂和还原剂，在不使用任何有害物质的情况下合成CP-MgONPs。通过先进的分析和显微镜技术确定所形成的CP-MgONPs的物理化学特征。对生物合成的CP-MgONPs的抗菌、抗癌和光催化特性进行了研究。
CP-MgONPs在紫外可见光谱中284nm处有一个明显的吸收峰，这是其显著特征。扫描电子显微镜（SEM）显示纳米颗粒呈多面体形态，CP-MgONPs略有团聚。CP-MgONPs对六种细菌菌株具有优异的抗菌效力。CP-MgONPs对[具体细菌1]（抑菌圈为20.72±0.33mm）和[具体细菌2]（抑菌圈为19.52±0.05mm）表现出显著敏感性，抑菌圈最大。评估了CP-MgONPs对HepG2（IC50：15.3μg·mL）癌细胞的抗癌作用，其表现出潜在的抗癌活性。在用CP-MgONPs处理的细胞中观察到细胞损伤迅速逆转，表现为细胞膜完整性受损、细胞凋亡和氧化应激。生物合成的CP-MgONPs在紫外光下使用酸性橙8（AO-8）染料时，与MgO粉末一样具有成功的光催化潜力。CP-MgONPs的降解性能在短时间内显示出对酸性橙8（AO-8）染料超过94%的光催化降解效率。
本研究结果表明，生物合成的CP-MgONPs在低浓度下可能具有优势，对环境有积极影响。
