综合膳食抗氧化指数与严重头痛或偏头痛之间的关联：来自美国国家健康与营养检查调查的结果
Association between the Composite Dietary Antioxidant Index and severe headache or migraine: results from the National Health and Nutrition Examination Survey.
作者信息
Zhang Zhiru, Chen Xushan, Fang Haotao, Ye Jiechao, Tang Xiaona, Huang Rucheng
机构信息
Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
Nursing Department, Baoan District Hospital of Traditional Chinese Medicine, Shenzhen, China.
出版信息
Front Neurol. 2024 Aug 1;15:1407243. doi: 10.3389/fneur.2024.1407243. eCollection 2024.
BACKGROUND
Severe headache or migraine is a neurological disease that seriously affects the quality of human life. Oxidative stress is considered a main factor in the pathogenesis of severe headache or migraine. The Composite Dietary Antioxidant Index (CDAI) is a score calculated using six dietary antioxidant components (including vitamins A, C, E, selenium, zinc, and carotenoid), which represents a person's level of dietary antioxidant ingredients. Based on the theory of oxidative stress, we speculated that CDAIs may be relevant to the risk of severe headache or migraine, as the relationship between the CDAI and severe headache or migraine is unclear. Hence, the purpose of this study was to explore the relationship between the CDAI and severe headache or migraine in participants.
METHODS
We performed a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) that were collected from 2001 to 2004. A total of 4,943 participants were included, of whom 1,232 experienced severe headaches or migraines. Participants' CDAIs were calculated based on their intake of six dietary antioxidants. We used logistic regression models, limited cubic spline analysis, and subgroup analysis to assess the association of CDAI with severe headache or migraine.
RESULTS
The multivariate logistic regression model (correcting for all potential covariates) revealed that the odds ratio (95% Confidence Interval [CI]) for the association between CDAI and severe headache or migraine was 0.97 (95% CI = 0.95-1.00, = 0.048). Compared with individuals with low CDAIs in Quartile (Q)1, the adjusted Odds Ratio between the CDAI and severe headache or migraine in Q2, Q3, and Q4 were 0.84 (95% CI = 0.69-1.01, = 0.07), 0.77 (95% CI = 0.63-0.96, = 0.017), and 0.73 (95% CI = 0.56-0.95, = 0.02), respectively. Restricted cubic spline regression analysis showed an L-shaped relationship between the CDAI and severe headache or migraine.
CONCLUSION
Our findings indicate that higher CDAI was associated with a lower risk of severe headache or migraine.
背景
重度头痛或偏头痛是一种严重影响人类生活质量的神经疾病。氧化应激被认为是重度头痛或偏头痛发病机制的主要因素。复合膳食抗氧化指数（CDAI）是通过六种膳食抗氧化成分（包括维生素A、C、E、硒、锌和类胡萝卜素）计算得出的分数，它代表了一个人的膳食抗氧化成分水平。基于氧化应激理论，由于CDAI与重度头痛或偏头痛之间的关系尚不清楚，我们推测CDAI可能与重度头痛或偏头痛的风险相关。因此，本研究的目的是探讨参与者中CDAI与重度头痛或偏头痛之间的关系。
方法
我们使用2001年至2004年收集的美国国家健康与营养检查调查（NHANES）数据进行了一项横断面研究。共纳入4943名参与者，其中1232人经历过重度头痛或偏头痛。根据参与者对六种膳食抗氧化剂的摄入量计算其CDAI。我们使用逻辑回归模型、受限立方样条分析和亚组分析来评估CDAI与重度头痛或偏头痛的关联。
结果
多变量逻辑回归模型（校正所有潜在协变量）显示，CDAI与重度头痛或偏头痛之间关联的比值比（95%置信区间[CI]）为0.97（95%CI = 0.95 - 1.00，P = 0.048）。与四分位数（Q）1中CDAI低的个体相比，Q2、Q3和Q4中CDAI与重度头痛或偏头痛之间的校正比值比分别为0.84（95%CI = 0.69 - 1.01，P = 0.07）、0.77（95%CI = 0.63 - 0.96，P = 0.017）和0.73（95%CI = 0.56 - 0.95，P = 0.02）。受限立方样条回归分析显示CDAI与重度头痛或偏头痛之间呈L形关系。
结论
我们的研究结果表明，较高的CDAI与较低的重度头痛或偏头痛风险相关。
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