Burger P C
Cancer. 1985 Oct 1;56(7 Suppl):1865-8. doi: 10.1002/1097-0142(19851001)56:7+<1865::aid-cncr2820561329>3.0.co;2-n.
The "ideal" classification of pediatric brain tumors will depend on a full characterization of pathologic variables and their influence on prognosis. Currently available information about these variables remains incomplete, even for traditional histologic and cytologic features, and certainly for those studied by the newer methods that will continue to appear. In light of the multiplicity and specialized nature of some of the techniques that are or will become available, it is suggested that specific pediatric central nervous system neoplasms be targeted for study by groups of pathologists according to a protocol that delegates specific studies to specific individuals. In light of the large number of cases required, as well as the need to control for effects of different treatments, such studies are most readily done within the framework of large cooperative clinical trials. Such organizations provide the mechanism to test the biologic significance of pathologic findings that can then be used in the ideal classification.
小儿脑肿瘤的“理想”分类将取决于对病理变量及其对预后影响的全面描述。目前关于这些变量的可用信息仍然不完整，即使是传统的组织学和细胞学特征也是如此，对于那些采用不断涌现的新方法研究的特征更是如此。鉴于一些现有或即将出现的技术具有多样性和专业性，建议由病理学家小组根据将特定研究委托给特定个体的方案，针对特定的小儿中枢神经系统肿瘤进行研究。鉴于所需病例数量众多，以及控制不同治疗效果的必要性，此类研究最适合在大型合作临床试验的框架内进行。这些组织提供了检验病理结果生物学意义的机制，进而可用于理想的分类。
