del Villar E, Mancilla J, Vega P, Sanchez E
Comp Biochem Physiol B. 1985;81(3):691-4. doi: 10.1016/0305-0491(85)90388-8.
Liver microsomes from alloxan diabetic rats displayed decreased activity to hydroxylate testosterone only at the 2-alpha and 6-beta positions. Diabetic insulin-treated rats showed higher hydroxylase activities than diabetic and control rats in the formation of all testosterone metabolites analyzed. The sodium dodecylsulfate electrophoretic profile of liver microsomal proteins from each group of rats exhibited distinct increases as well as decreases in the cytochrome P-450 region. Stimulation of testosterone metabolism by insulin may be associated with a higher synthesis of certain cytochrome P-450 isozymes.
四氧嘧啶糖尿病大鼠的肝微粒体仅在2-α和6-β位显示出睾酮羟化活性降低。在分析的所有睾酮代谢产物形成过程中，糖尿病胰岛素治疗大鼠的羟化酶活性高于糖尿病大鼠和对照大鼠。每组大鼠肝微粒体蛋白的十二烷基硫酸钠电泳图谱在细胞色素P-450区域呈现出明显的增加和减少。胰岛素对睾酮代谢的刺激可能与某些细胞色素P-450同工酶的合成增加有关。
