Alharbi Badr, Alqossayir Fuhaid, Moalwi Adel, Alwashmi Emad, Alharbi Adel H, Aloraini Abdullah, Aljumah Arwa, Alhomaidhi Manahil, Almansour Mohammed
Department of Surgery, College of Medicine, Qassim University, Buraydah, SAU.
Department of Family and Community Medicine, College of Medicine, Qassim University, Buraydah, SAU.
Cureus. 2024 Jun 4;16(6):e61632. doi: 10.7759/cureus.61632. eCollection 2024 Jun.
In the past, fertility concerns have predominantly revolved around the effect of a woman's age on the quality of her eggs and the success of her pregnancy. While men generally retain their ability to father children throughout their lives, there is evidence suggesting a decline in natural conception rates as paternal age increases. A growing body of research indicates a potential link between advanced paternal age (APA) and various adverse outcomes, including changes in sperm genetics, reduced conception rates, higher rates of miscarriage, lower live birth rates, and even long-term health consequences in offspring. However, it remains unclear whether there is an association between APA and the effectiveness of assisted reproductive technology (ART). This study aims to shed light on the relationship between APA and semen parameters.
This is a retrospective, descriptive study analyzing data from electronic medical records of men undergoing ART at a fertility clinic in Saudia Arabia (2017-2022). Men aged 21-60 with at least one semen analysis and no missing data/hormonal treatment were included. Data on age and semen parameters (count, motility, and morphology) were extracted and analyzed using Jeffreys's Amazing Statistics Program (JASP; University of Amsterdam, Amsterdam, Netherlands) (descriptive statistics, Spearman's rank correlation).
Analysis of 1506 men undergoing ART revealed a mean age of 37 years (SD=6.94) and a mean sperm count of 55.0 million/mL (SD=46.05). The correlation between age and sperm count indicates a minimal association (r=0.075, p<0.01); moderate positive correlations were observed between sperm count and motility (r=0.406); count and morphology (r=0.543); and motility and morphology (r=0.458).
Age may not be a major factor in overall sperm parameters for this population, but a strong positive correlation was observed between sperm count, motility, and normal morphology. These findings suggest that these semen parameters are interconnected, with higher sperm counts potentially indicating better overall sperm quality.
过去，生育问题主要围绕女性年龄对卵子质量和怀孕成功率的影响。虽然男性通常在一生中都保持生育能力，但有证据表明，随着父亲年龄的增加，自然受孕率会下降。越来越多的研究表明，高龄父亲（APA）与各种不良后果之间存在潜在联系，包括精子基因变化、受孕率降低、流产率升高、活产率降低，甚至对后代有长期健康影响。然而，目前尚不清楚APA与辅助生殖技术（ART）的有效性之间是否存在关联。本研究旨在阐明APA与精液参数之间的关系。
这是一项回顾性描述性研究，分析了沙特阿拉伯一家生育诊所（2017 - 2022年）接受ART治疗的男性电子病历数据。纳入年龄在21 - 60岁之间、至少进行过一次精液分析且无数据缺失/激素治疗的男性。使用杰弗里斯神奇统计程序（JASP；荷兰阿姆斯特丹大学）提取并分析年龄和精液参数（数量、活力和形态）数据（描述性统计、斯皮尔曼等级相关性）。
对1506名接受ART治疗的男性进行分析，其平均年龄为37岁（标准差 = 6.94），平均精子数量为5500万/mL（标准差 = 46.05）。年龄与精子数量之间的相关性表明关联极小（r = 0.075，p < 0.01）；精子数量与活力之间观察到中度正相关（r = 0.406）；数量与形态之间（r = 0.543）；活力与形态之间（r = 0.458）。
对于该人群，年龄可能不是总体精子参数的主要因素，但在精子数量、活力和正常形态之间观察到强正相关。这些发现表明这些精液参数相互关联，较高的精子数量可能表明总体精子质量更好。
