印度男性精液质量在过去 37 年中下降。
Decline in seminal quality in Indian men over the last 37 years.
机构信息
Male Reproductive Biology Laboratory, Division of Endocrinology, Central Drug Research Institute, Lucknow, UP, India.
Division of Toxicology and Experimental Medicine, Central Drug Research Institute, Lucknow, UP, India.
出版信息
Reprod Biol Endocrinol. 2018 Oct 23;16(1):103. doi: 10.1186/s12958-018-0425-z.
BACKGROUND
Since the first report of a decline in semen quality in 1974, there have been several reports of similar declines across populations. Despite some scattered reports of declining semen quality in the Indian sub-continent, comprehensive studies analyzing semen quality over the last few decades have not been undertaken. We undertook the present study to investigate the temporal trend in semen parameters in Indian populations over a period of 37 years (1979-2016).
METHODS
Publications providing semen analysis details for fertile and infertile men from the Indian sub-continent were collected by a thorough literature search. Semen quality data for 6466 normal fertile or presumptive normal men (from 119 studies/data sets) and 7020 infertile men (from 63 studies/data sets) published between 1979 and 2016 were retrieved. We undertook systematic review and quantitative analysis of mean sperm count, motility, normal morphology and other available parameters. Data were analyzed to estimate semen parameters reference values for Indian men and to assess temporal trends in infertile, fertile and all subjects.
RESULTS
Seminal quality shows a decreasing temporal trend and the decrease is higher in infertile than fertile males. In pooled analysis for all individuals, significant (p < 0.05 or < 0.001) declines in sperm concentration and normal morphology are observed; however, isolated analysis for each group shows declines without statistical significance. The mean (± SD) semen volume, sperm concentration, total motility, rapid linear progressive motility, normal sperm morphology and sperm viability for Indian fertile men are 2.88 ± 0.77 ml, 81.08 ± 29.21 million/ml, 66.37 ± 10.95%, 52.64 ± 15.78%, 56.68 ± 20.23% and 72.63 ± 8.31%, respectively, whereas in infertile these are 3.07 ± 1.27 ml, 37.94 ± 26.41 million/ml, 40.22 ± 13.76%, 26.79 ± 15.47%, 36.41 ± 21.66% and 55.25 ± 11.99%, respectively. The mean seminal parameter values were significantly lower (p < 0.001) in infertile as compared to fertile men, except semen volume.
CONCLUSIONS
Semen parameters in Indian men have declined with time and the deterioration is quantitatively higher in the infertile group. The study also provides reference values for semen parameters in Indian men.
背景
自 1974 年首次报道精液质量下降以来，已有多项研究报告称人群中也存在类似的下降趋势。尽管印度次大陆有一些关于精液质量下降的零散报告，但过去几十年并没有进行全面分析精液质量的综合研究。我们进行了本研究，以调查过去 37 年来（1979-2016 年）印度人群精液参数的时间趋势。
方法
通过全面的文献检索，收集了来自印度次大陆提供精液分析详细信息的出版物。从 1979 年至 2016 年期间发表的 119 项研究/数据集，检索到 6466 名正常生育或疑似正常男性（正常生育组）和 63 项研究/数据集，7020 名不育男性（不育组）的精液质量数据。我们进行了系统综述和定量分析，以评估精子计数、活力、正常形态等参数的平均值。分析数据以估算印度男性的精液参数参考值，并评估不育、正常生育和所有人群的时间趋势。
结果
精液质量呈下降趋势，不育男性的下降幅度高于正常生育男性。在所有个体的汇总分析中，观察到精子浓度和正常形态有显著（p<0.05 或<0.001）下降；然而，对每个组的单独分析显示没有统计学意义的下降。印度正常生育男性的精液量、精子浓度、总活力、快速直线前向运动精子比例、正常精子形态和精子活力的平均值（±SD）分别为 2.88±0.77ml、81.08±29.21 百万/ml、66.37±10.95%、52.64±15.78%、56.68±20.23%和 72.63±8.31%，而不育男性的分别为 3.07±1.27ml、37.94±26.41 百万/ml、40.22±13.76%、26.79±15.47%、36.41±21.66%和 55.25±11.99%。与正常生育男性相比，不育男性的平均精液参数值显著降低（p<0.001），除精液量外。
结论
印度男性的精液参数随时间推移而下降，不育组的恶化程度在数量上更高。该研究还为印度男性的精液参数提供了参考值。
Zotero 插件