Blumer J L, Aronoff S C, Myers C M, O'Brien C A, Klinger J D, Reed M D
Dev Pharmacol Ther. 1985;8(4):219-31. doi: 10.1159/000457041.
The single dose pharmacokinetics and cerebrospinal fluid (CSF) penetration of ceftazidime were determined in 10 children with bacterial meningitis. Serum ceftazidime pharmacokinetics showed a distinct age dependence in which the clearance in children less than 1 month of age was markedly reduced. Ceftazidime concentrations in CSF, which ranged from 1.4-8.5 micrograms/ml, exceeded the minimum bactericidal concentrations for infecting pathogens throughout the 8-hour sampling period. These concentrations were found to be independent of CSF cell count, protein concentration or the day of therapy on which the study was performed. The ratio of CSF to serum ceftazidime concentration increased with time, suggesting that ceftazidime was cleared more slowly from CSF than from peripheral blood. Our data support the initiation of a study comparing the efficacy of ceftazidime to conventional therapy in children with bacterial meningitis.
在10例细菌性脑膜炎患儿中测定了头孢他啶的单剂量药代动力学及脑脊液（CSF）渗透率。血清头孢他啶药代动力学显示出明显的年龄依赖性，其中1个月龄以下儿童的清除率显著降低。脑脊液中头孢他啶浓度范围为1.4 - 8.5微克/毫升，在整个8小时采样期间均超过感染病原体的最低杀菌浓度。发现这些浓度与脑脊液细胞计数、蛋白质浓度或进行研究的治疗天数无关。脑脊液与血清中头孢他啶浓度的比值随时间增加，表明头孢他啶从脑脊液中的清除比从外周血中更慢。我们的数据支持开展一项比较头孢他啶与传统疗法对细菌性脑膜炎患儿疗效的研究。
