Oh Tak Kyu, Song In-Ae, Jeon Young-Tae
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, South Korea; Interdepartment of Critical Care Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, South Korea; Interdepartment of Critical Care Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Clin Neurol Neurosurg. 2024 Sep;244:108405. doi: 10.1016/j.clineuro.2024.108405. Epub 2024 Jun 23.
This study aimed to investigate the effects of traumatic brain injury (TBI) on employment status, household income, and the development of new disabilities among survivors, as well as its correlation with mortality rates over a 2-year period.
In this nationwide population-based cohort study, we screened all patients admitted to the intensive care unit (ICU) because of TBI between January 1, 2010, and December 31, 2018, in South Korea. Among them, patients who were alive for > 1 year were considered TBI survivors. Changes in unemployment, decreased household income, and newly acquired disabilities were evaluated one year after the date of ICU admission due to TBI.
In total, 78,420 TBI survivors were included in this study. Among them, 5.4 %, 22.5 %, and 8.6 % of the TBI survivors experienced unemployment, decreased household income, and newly acquired disabilities within one year after the date of ICU admission, respectively. A longer ICU stay, comorbidities, hospital admission through the emergency room, increased total cost of hospitalization, and mechanical ventilatory support were associated with unemployment, decreased household income, and newly acquired disabilities. Among the three factors, the newly acquired disability was associated with a 27 % increase in 2-year all-cause mortality (hazard ratio: 1.27, 95 % confidence interval: 1.17-1.39; P < 0.001), while unemployment and decreased household income were not significantly associated (P = 0.371 and P = 0.105, respectively).
A significant number of individuals in South Korea who survived TBI faced challenges such as unemployment, reduced household income, and the acquisition of new disabilities within a year of being admitted to the ICU. In addition, the study found that individuals who developed a new disability after TBI had a higher risk of mortality within two years.
本研究旨在调查创伤性脑损伤(TBI)对幸存者就业状况、家庭收入以及新残疾发生情况的影响,及其与2年期间死亡率的相关性。
在这项基于全国人群的队列研究中,我们筛选了2010年1月1日至2018年12月31日期间因TBI入住韩国重症监护病房(ICU)的所有患者。其中,存活超过1年的患者被视为TBI幸存者。在因TBI入住ICU之日起1年后,评估失业、家庭收入减少和新获得残疾情况的变化。
本研究共纳入78420名TBI幸存者。其中,分别有5.4%、22.5%和8.6%的TBI幸存者在入住ICU之日起1年内经历了失业、家庭收入减少和新获得残疾。ICU住院时间延长、合并症、通过急诊室入院、住院总费用增加以及机械通气支持与失业、家庭收入减少和新获得残疾相关。在这三个因素中,新获得残疾与2年全因死亡率增加27%相关(风险比:1.27,95%置信区间:1.17 - 1.39;P < 0.001),而失业和家庭收入减少无显著相关性(分别为P = 0.371和P = 0.105)。
韩国大量TBI幸存者在入住ICU后1年内面临失业、家庭收入减少和新获得残疾等挑战。此外,研究发现TBI后出现新残疾的个体在两年内死亡风险更高。