Laboratorio de Osteopatías y Metabolismo Mineral (LIOMM), Facultad de Cs. Exactas. Universidad Nacional de La Plata UNLP-CIC, Argentina.
Biochemistry Research Institute of La Plata "Professor Doctor Rodolfo R. Brenner" (INIBIOLP), Argentina.
Ageing Res Rev. 2024 Aug;99:102408. doi: 10.1016/j.arr.2024.102408. Epub 2024 Jul 3.
Alzheimer's disease (AD) and osteoporosis are two diseases that mainly affect elderly people, with increases in the occurrence of cases due to a longer life expectancy. Several epidemiological studies have shown a reciprocal association between both diseases, finding an increase in incidence of osteoporosis in patients with AD, and a higher burden of AD in osteoporotic patients. This epidemiological relationship has motivated the search for molecules, genes, signaling pathways and mechanisms that are related to both pathologies. The mechanisms found in these studies can serve to improve treatments and establish better patient care protocols.
阿尔茨海默病（AD）和骨质疏松症是两种主要影响老年人的疾病，由于预期寿命的延长，病例的发生率有所增加。几项流行病学研究表明，这两种疾病之间存在相互关联，即在 AD 患者中发现骨质疏松症的发病率增加，而在骨质疏松症患者中 AD 的负担更高。这种流行病学关系促使人们寻找与这两种疾病相关的分子、基因、信号通路和机制。这些研究中发现的机制可以用于改善治疗方法并制定更好的患者护理方案。
